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How to get fromMayo Clinic to Detroitby plane, bus (Flixbus), bus, train, car, or bus (Amtrak)

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There are 8 ways to get from Mayo Clinic to Detroit by plane, bus (Flixbus), bus, train, car, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Detroit

    best
    1. Fly from Rochester (RST) to Detroit (DTW)plane plane RST - DTW
    7h 12m
    $83–529

  2. Fly Rochester to Bishop International Airport, bus

    cheapest
    1. Fly from Rochester (RST) to Bishop International Airport (FNT)plane plane RST - FNT
    2. Take the bus from Flint to Detroit Bus Stationbus bus
    8h 47m
    $69–411

  3. Bus

    1. Take the bus from Rochester to Milwaukeebus bus Jefferson Lines 965
    2. Take the bus from Milwaukee Intermodal Station to Detroit Bus Stationbus bus FlixBus 2550
    14h 18m
    $120–181

  4. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Detroittrain train
    16h 30m
    $214–459

  5. Drive  627.3 mi

    1. Drive from Mayo Clinic to Detroitcar car 627.3 mi
    10h 20m
    $115–166

  6. Bus to Minneapolis–Saint Paul International Airport, fly to Detroit

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Detroit (DTW)plane plane MSP - DTW
    5h 25m
    $522–1,252

  7. Bus, train via Madison

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Detroittrain train
    15h 51m
    $155–304

  8. Bus via Chicago

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago Union Station to Detroitbus bus
    15h 51m
    $165–264

Mayo Clinic to Detroit by foot and bus

Calendar4Weekly Services
Duration14h 18mAverage Duration
Ticket$120Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to Detroit.ExpandLaunch map view
  • Distance: 506.8 mi
  • Duration: 7h 12m

What companies run services between Mayo Clinic, MN, USA and Detroit, MI, USA?

American Airlines, Delta, and United Airlines fly from Rochester (RST) to Detroit (DTW) every 3 hours. Alternatively, you can take a vehicle from Mayo Clinic to Detroit Bus Station via Rochester, Milwaukee, and Milwaukee Intermodal Station in around 14h 18m.

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