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How to get fromMayo Clinic to Detroitby plane, bus (Flixbus), bus, train, or car

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There are 7 ways to get from Mayo Clinic to Detroit by plane, bus (Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Detroit

    best
    1. Fly from Rochester (RST) to Detroit (DTW)plane plane RST - DTW
    6h 58m
    $153–889

  2. Drive 627.3 mi

    cheapest
    1. Drive from Mayo Clinic to Detroitcar car 627.3 mi
    10h 20m
    $115–166

  3. Bus

    1. Take the bus from Rochester, MN to Milwaukee, WI - Amtrakbus bus Minneapolis / ...
    2. Take the bus from Milwaukee Intermodal Station to Detroit Bus Stationbus bus FlixBus 2550
    14h 58m
    $129–201

  4. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Detroittrain train
    16h 15m
    $249–499

  5. Bus to Minneapolis–Saint Paul International Airport, fly to Detroit

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Detroit (DTW)plane plane MSP - DTW
    5h 28m
    $522–1,252

  6. Fly Rochester to Bishop International Airport, bus

    1. Fly from Rochester (RST) to Bishop International Airport (FNT)plane plane RST - FNT
    2. Take the bus from Flint to Detroit Bus Stationbus bus
    8h 17m
    $120–703

  7. Bus, train via Madison

    1. Take the bus from Rochester, MN to UW-Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Detroittrain train
    16h 31m
    $174–329

Mayo Clinic to Detroit by foot and bus

Calendar4Weekly Services
Duration14h 58mAverage Duration
Ticket$129Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to Detroit.ExpandLaunch map view
  • Distance: 506.8 mi
  • Duration: 6h 58m

What companies run services between Mayo Clinic, MN, USA and Detroit, MI, USA?

American Airlines, United Airlines, and Delta fly from Rochester (RST) to Detroit (DTW) every 4 hours. Alternatively, you can take a vehicle from Mayo Clinic to Detroit Bus Station via Rochester, MN and Milwaukee Intermodal Station in around 14h 58m.

Airlines
Train operators
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