There are 5 ways to get from Mayo Clinic to Fort Wayne by plane, bus, car, or bus (Flixbus, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Rochester
best- Fly from Rochester (RST) to Fort Wayne International Airport (FWA)plane RST - FWA
6h 22m$91–422Bus via Chicago
- Take the bus from Rochester to Madisonbus
- Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus
- Take the bus from Chicago to Fort Waynebus
15h 3m$98–191Drive 502.8 mi
- Drive from Mayo Clinic to Fort Waynecar 502.8 mi
8h 55m$92–133Bus to Minneapolis–Saint Paul International Airport, fly
- Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus
- Fly from Minneapolis–Saint Paul International Airport (MSP) to Fort Wayne International Airport (FWA)plane MSP - FWA
4h 29m$160–545Bus
- Take the bus from Rochester to Madisonbus
- Take the bus from Madison to Chicago Bus Stationbus
- Take the bus from Chicago to Fort Waynebus
15h 29m$97–176
Mayo Clinic to Fort Wayne by foot and bus
Comparing Your Travel Options
The cheapest way to get from Mayo Clinic to Fort Wayne is to drive which costs $90 - $140 and takes 8h 55m.
The fastest way to get from Mayo Clinic to Fort Wayne is to bus and fly which takes 4h 29m and costs $160 - $550.
No, there is no direct bus from Mayo Clinic to Fort Wayne. However, there are services departing from Rochester and arriving at Coldwater at Stratton via 250 N. Lake St - Madison UW Campus, Chicago and Central Station - Bay A. The journey, including transfers, takes approximately 15h 3m.
The distance between Mayo Clinic and Fort Wayne is 447 miles. The road distance is 505.7 miles.
The best way to get from Mayo Clinic to Fort Wayne without a car is to bus via Chicago which takes 15h 3m and costs $95 - $200.
It takes approximately 6h 22m to get from Mayo Clinic to Fort Wayne, including transfers.
Mayo Clinic to Fort Wayne bus services, operated by Jefferson Lines, depart from Rochester station.
The best way to get from Mayo Clinic to Fort Wayne is to fly which takes 6h 22m and costs $90 - $430. Alternatively, you can bus via Chicago, which costs $95 - $200 and takes 15h 3m.
Mayo Clinic to Fort Wayne bus services, operated by Jefferson Lines, arrive at Madison station.
Yes, the driving distance between Mayo Clinic to Fort Wayne is 506 miles. It takes approximately 8h 55m to drive from Mayo Clinic to Fort Wayne.
What companies run services between Mayo Clinic, MN, USA and Fort Wayne, IN, USA?
American Airlines and Delta fly from Rochester (RST) to Fort Wayne International Airport (FWA) 3 times a day. Alternatively, you can take a vehicle from Mayo Clinic to Coldwater at Stratton via Rochester, Madison, 250 N. Lake St - Madison UW Campus, W Jackson Blvd, after S Clinton St, Chicago, Fort Wayne, and Central Station - Bay A in around 15h 3m.
- Website
- united.com
Flights from Minneapolis–Saint Paul International Airport to Fort Wayne International Airport via Chicago O'Hare
- Ave. Duration
- 4h 5m
- When
- Every day
- Estimated price
- $75–450
- Website
- aa.com
Flights from Rochester to Fort Wayne International Airport via Chicago O'Hare
- Ave. Duration
- 5h 45m
- When
- Every day
- Estimated price
- $55–340
- Website
- delta.com
Flights from Rochester to Fort Wayne International Airport via Minneapolis–Saint Paul International Airport
- Ave. Duration
- 5h 33m
- When
- Every day
- Estimated price
- $60–370
Flights from Minneapolis–Saint Paul International Airport to Fort Wayne International Airport
- Ave. Duration
- 1h 41m
- When
- Every day
- Estimated price
- $75–450
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Rochester to Madison
- Ave. Duration
- 4h 15m
- Frequency
- Once daily
- Estimated price
- $50–75
- Book at
- Jefferson Lines
- Adult
- $50–75
Bus from Rochester to Madison
- Ave. Duration
- 4h 15m
- Frequency
- Once daily
- Estimated price
- $50–75
- Book at
- Jefferson Lines
- Adult
- $50–75
- Phone
- +1 (866) 912 - 6224
- [email protected]
- Website
- Rockland Coaches
Bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton St
- Ave. Duration
- 4h
- Frequency
- Hourly
- Estimated price
- $26–60
- Schedules at
- Rockland Coaches
- Adult
- $26–60
- Phone
- +1 888-378-3823
- [email protected]
- Website
- Barons Bus
Bus from Chicago to Fort Wayne
- Ave. Duration
- 4h 5m
- Frequency
- Twice daily
- Estimated price
- $16–55
- Website
- Barons Bus
Bus from Chicago to Fort Wayne
- Ave. Duration
- 4h 5m
- Frequency
- Twice daily
- Estimated price
- $16–55
- Website
- Barons Bus
Bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airport
- Ave. Duration
- 1h
- Frequency
- Every 4 hours
- Estimated price
- $40–50
- Website
- Groome Transportation - Rochester - MSP
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Madison to Chicago Bus Station
- Ave. Duration
- 4h 10m
- Frequency
- Twice daily
- Estimated price
- $25–40
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Madison to Chicago Bus Station
- Ave. Duration
- 3h 5m
- Frequency
- Once daily
- Estimated price
- $28–45
- Website
- Greyhound
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Booking & Getting There
There are 88+ hotels available in Fort Wayne.