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How to get fromMayo Clinic to Hilton Head Islandby plane, taxi, bus, train, or car

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There are 8 ways to get from Mayo Clinic to Hilton Head Island by plane, taxi, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Savannah, taxi

    best
    1. Fly from Rochester (RST) to Savannah (SAV)plane plane RST - SAV
    2. Take the taxi from Savannah (SAV) to Hilton Head Islandtaxi taxi
    10h 25m
    $281–877

  2. Fly Rochester to Hilton Head Airport

    cheapest
    1. Fly from Rochester (RST) to Hilton Head Airport (HHH)plane plane RST - HHH
    8h 2m
    $96–497

  3. Bus, train, taxi via Atlanta

    1. Take the bus from Rochester to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus
    5. Take the train from Charleston Amtrak Station to Savannah Stationtrain train
    6. Take the taxi from Savannah Station to Hilton Head Islandtaxi taxi
    41h 33m
    $433–732

  4. Bus, train, taxi

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Savannah Stationtrain train
    4. Take the taxi from Savannah Station to Hilton Head Islandtaxi taxi
    42h 47m
    $680–1,274

  5. Drive 1,261.5 mi

    1. Drive from Mayo Clinic to Hilton Head Islandcar car 1,261.5 mi
    22h 33m
    $231–333

  6. Bus to Minneapolis–Saint Paul International Airport, fly to Savannah, taxi

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Savannah (SAV)plane plane MSP - SAV
    3. Take the taxi from Savannah (SAV) to Hilton Head Islandtaxi taxi
    5h 59m
    $360–990

  7. Bus to Minneapolis–Saint Paul International Airport, fly to Hilton Head Airport

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Hilton Head Airport (HHH)plane plane MSP - HHH
    8h 33m
    $170–600

  8. Bus, train, taxi #2

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Savannah Stationtrain train
    4. Take the taxi from Savannah Station to Hilton Head Islandtaxi taxi
    43h 46m
    $759–1,449

Rochester (RST) to Savannah (SAV) flights

Calendar35Weekly Planes
Duration10h 18mAverage Duration
Ticket$133Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to Hilton Head Island.ExpandLaunch map view
  • Distance: 1,064.1 mi
  • Duration: 10h 25m

What companies run services between Mayo Clinic, MN, USA and Hilton Head Island, SC, USA?

American Airlines, United Airlines, and Delta fly from Rochester (RST) to Hilton Head Airport (HHH) 3 times a day.

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