Rome2Rio

How to get fromMayo Clinic to Illinoisby plane, bus (Greyhound, Flixbus), bus, train, or car

Find Transport to Illinois

See all options

There are 8 ways to get from Mayo Clinic to Illinois by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Chicago O'Hare International Airport

    best
    1. Fly from Rochester (RST) to Chicago O'Hare International Airport (ORD)plane plane RST - ORD
    3h 37m
    $38–292

  2. Bus

    1. Take the bus from Rochester, MN to Wisconsin Dellsbus bus Minneapolis
    2. Take the bus from Wisconsin Dells to Chicago Bus Stationbus bus Greyhound US0150
    8h 43m
    $77–125

  3. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus Jefferson 966 / ...
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train Borealis / ...
    9h 55m
    $159–309

  4. Drive 347 mi

    1. Drive from Mayo Clinic to Chicagocar car 347 mi
    5h 42m
    $64–92

  5. Bus to Minneapolis–Saint Paul International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Chicago Midway International Airport (MDW)plane plane MSP - MDW
    4h 30m
    $107–415

  6. Bus to Minneapolis–Saint Paul International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Chicago O'Hare International Airport (ORD)plane plane MSP - ORD
    4h 41m
    $272–505

  7. Bus, train via Milwaukee

    1. Take the bus from Rochester, MN to Milwaukee, WI - Amtrakbus bus Minneapolis / ...
    2. Take the train from Milwaukee to Chicago Union Stationtrain train Hiawatha Service / ...
    9h 2m
    $101–161

  8. Bus via Madison

    1. Take the bus from Rochester, MN to UW-Madisonbus bus Minneapolis / ...
    2. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 2 Departuresbus bus Van Galder
    9h 28m
    $83–134

Mayo Clinic to Illinois by foot and bus

Calendar14Weekly Services
Duration8h 43mAverage Duration
Ticket$77Cheapest Price
See schedules

Questions & Answers

Map of how to get from Mayo Clinic to Illinois.ExpandLaunch map view
  • Distance: 294.2 mi
  • Duration: 3h 37m

What companies run services between Mayo Clinic, MN, USA and Illinois, USA?

American Airlines and United Airlines fly from Rochester (RST) to Chicago O'Hare International Airport (ORD) 4 times a day. Alternatively, you can take a vehicle from Mayo Clinic to Chicago Bus Station via Rochester, MN and Wisconsin Dells in around 8h 43m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers