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How to get fromMayo Clinic to Ithacaby plane, bus, train, bus (Greyhound, Flixbus), car, or bus (Flixbus)

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There are 11 ways to get from Mayo Clinic to Ithaca by plane, bus, train, bus (Greyhound, Flixbus), car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Rochester, bus

    best
    1. Fly from Rochester (RST) to Rochester (ROC)plane plane RST - ROC
    2. Take the bus from Rochester to Ithacabus bus
    8h 36m
    $190–916

  2. Bus

    cheapest
    1. Take the bus from Rochester to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago to Clevelandbus bus
    4. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    5. Take the bus from Buffalo to Ithacabus bus
    25h 18m
    $155–298

  3. Bus, train via Madison

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Syracuse Regional Transportation Centertrain train
    4. Take the bus from Syracuse Bus Station to Ithacabus bus
    25h 6m
    $259–538

  4. Drive  1,003.7 mi

    1. Drive from Mayo Clinic to Ithacacar car 1,003.7 mi
    17h 23m
    $184–265

  5. Fly Rochester to Syracuse Hancock International Airport, bus

    1. Fly from Rochester (RST) to Syracuse Hancock International Airport (SYR)plane plane RST - SYR
    2. Take the bus from Syracuse Bus Station to Ithacabus bus
    9h 6m
    $173–928

  6. Bus to Minneapolis–Saint Paul International Airport, fly to Ithaca Tompkins Regional Airport

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Ithaca Tompkins Regional Airport (ITH)plane plane MSP - ITH
    9h 23m
    $170–650

  7. Bus to Minneapolis–Saint Paul International Airport, fly to Syracuse Hancock International Airport, bus

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Syracuse Hancock International Airport (SYR)plane plane MSP - SYR
    3. Take the bus from Syracuse Bus Station to Ithacabus bus
    7h 54m
    $252–1,091

  8. Bus to Minneapolis–Saint Paul International Airport, fly to Buffalo Niagara International Airport, bus

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Buffalo Niagara International Airport (BUF)plane plane MSP - BUF
    3. Take the bus from Buffalo Niagara International Airport to Ithacabus bus
    8h 49m
    $203–785

  9. Bus to Minneapolis–Saint Paul International Airport, fly to Elmira/Corning Regional Airport, bus

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Elmira/Corning Regional Airport (ELM)plane plane MSP - ELM
    3. Take the bus from Transit Center - PO Side to Tompkins County Librarybus bus
    10h 37m
    $155–609

  10. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Syracuse Regional Transportation Centertrain train
    4. Take the bus from Syracuse Bus Station to Ithacabus bus
    26h 17m
    $308–683

  11. Bus via Detroit

    1. Take the bus from Rochester to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Detroit Bus Stationbus bus
    3. Take the bus from Detroit Bus Station to Torontobus bus
    4. Take the bus from Toronto to Ithacabus bus
    30h 13m
    $200–306

Mayo Clinic to Ithaca by foot, bus, and train

Calendar3Weekly Services
Duration25h 6mAverage Duration
Ticket$259Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mayo Clinic to Ithaca.ExpandLaunch map view
  • Distance: 848.4 mi
  • Duration: 8h 36m

What companies run services between Mayo Clinic, MN, USA and Ithaca, NY, USA?

You can take a vehicle from Mayo Clinic to Ithaca via Rochester, Milwaukee, Milwaukee Intermodal Station, Chicago, Cleveland, OH, Buffalo, NY, and Buffalo in around 25h 18m.

Airlines
Train operators
Bus operators

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