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How to get fromMayo Clinic to Ithacaby plane, bus, train, bus (Greyhound, Flixbus), or car

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There are 10 ways to get from Mayo Clinic to Ithaca by plane, bus, train, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Rochester, bus

    best
    1. Fly from Rochester (RST) to Rochester (ROC)plane plane RST - ROC
    2. Take the bus from Rochester to Ithacabus bus
    8h 37m
    $304–1,399

  2. Bus to Minneapolis–Saint Paul International Airport, fly to Elmira/Corning Regional Airport, bus

    cheapest
    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Elmira/Corning Regional Airport (ELM)plane plane MSP - ELM
    3. Take the bus from Transit Center - PO Side to Tompkins County Librarybus bus
    11h 8m
    $155–549

  3. Bus, train via Madison

    1. Take the bus from Rochester, MN to UW-Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Rochestertrain train
    4. Take the bus from Rochester to Ithacabus bus 231
    24h 39m
    $294–584

  4. Bus

    1. Take the bus from Rochester, MN to Milwaukee, WI - Amtrakbus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago to Clevelandbus bus
    4. Take the bus from Cleveland to Buffalobus bus
    5. Take the bus from Buffalo to Ithacabus bus
    26h 10m
    $181–389

  5. Drive 1,003.7 mi

    1. Drive from Mayo Clinic to Ithacacar car 1,003.7 mi
    17h 23m
    $184–265

  6. Bus to Minneapolis–Saint Paul International Airport, fly to Ithaca Tompkins Regional Airport

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Ithaca Tompkins Regional Airport (ITH)plane plane MSP - ITH
    8h 57m
    $170–650

  7. Fly Rochester to Syracuse Hancock International Airport, bus

    1. Fly from Rochester (RST) to Syracuse Hancock International Airport (SYR)plane plane RST - SYR
    2. Take the bus from Syracuse Bus Station to Ithacabus bus
    8h 33m
    $318–1,564

  8. Bus to Minneapolis–Saint Paul International Airport, fly to Syracuse Hancock International Airport, bus

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Syracuse Hancock International Airport (SYR)plane plane MSP - SYR
    3. Take the bus from Syracuse Bus Station to Ithacabus bus
    7h 51m
    $243–994

  9. Bus to Minneapolis–Saint Paul International Airport, fly to Buffalo Niagara International Airport, bus

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Buffalo Niagara International Airport (BUF)plane plane MSP - BUF
    3. Take the bus from Buffalo Niagara International Airport to Ithacabus bus
    8h 46m
    $240–915

  10. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Syracuse Regional Transportation Centertrain train
    4. Take the bus from Syracuse Bus Station to Ithacabus bus
    25h 57m
    $379–766

Mayo Clinic to Ithaca by foot, bus, and train

Calendar14Weekly Services
Duration24h 39mAverage Duration
Ticket$294Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to Ithaca.ExpandLaunch map view
  • Distance: 848.4 mi
  • Duration: 8h 37m

What companies run services between Mayo Clinic, MN, USA and Ithaca, NY, USA?

You can take a vehicle from Mayo Clinic to Ithaca via Rochester, MN, Milwaukee Intermodal Station, Chicago, Cleveland, and Buffalo in around 26h 10m.

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Train operators
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