There are 5 ways to get from Mayo Clinic to Milwaukee by bus, car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Rochester to Milwaukeebus Jefferson Lines 965
5h 53m$70–100Drive 275 mi
cheapest- Drive from Mayo Clinic to Milwaukeecar 275 mi
4h 32m$51–73Fly Rochester to General Mitchell International Airport
- Fly from Rochester (RST) to General Mitchell International Airport (MKE)plane RST - MKE
5h 8m$74–510Bus to Minneapolis–Saint Paul International Airport, fly to General Mitchell International Airport
- Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus
- Fly from Minneapolis–Saint Paul International Airport (MSP) to General Mitchell International Airport (MKE)plane MSP - MKE
4h 14m$653–1,053Fly Rochester to Chicago O'Hare International Airport, bus
- Fly from Rochester (RST) to Chicago O'Hare International Airport (ORD)plane RST - ORD
- Take the bus from Chicago to Milwaukee Intermodal Stationbus
5h 26m$51–303
Mayo Clinic to Milwaukee by foot and bus
Comparing Your Travel Options
The cheapest way to get from Mayo Clinic to Milwaukee is to drive which costs $50 - $75 and takes 4h 32m.
The fastest way to get from Mayo Clinic to Milwaukee is to bus and fly which takes 4h 14m and costs $650 - $1,100.
Yes, there is a direct bus departing from Rochester and arriving at Milwaukee. Services depart once daily, and operate every day. The journey takes approximately 5h 45m.
The distance between Mayo Clinic and Milwaukee is 280 miles. The road distance is 276.6 miles.
The best way to get from Mayo Clinic to Milwaukee without a car is to bus which takes 5h 53m and costs $70 - $100.
The bus from Rochester to Milwaukee takes 5h 45m including transfers and departs once daily.
Mayo Clinic to Milwaukee bus services, operated by Jefferson Lines, depart from Rochester station.
The best way to get from Mayo Clinic to Milwaukee is to bus which takes 5h 53m and costs $70 - $100. Alternatively, you can fly, which costs $70 - $550 and takes 5h 8m.
Mayo Clinic to Milwaukee bus services, operated by Jefferson Lines, arrive at Milwaukee station.
Yes, the driving distance between Mayo Clinic to Milwaukee is 277 miles. It takes approximately 4h 32m to drive from Mayo Clinic to Milwaukee.
What companies run services between Mayo Clinic, MN, USA and Milwaukee, WI, USA?
Jefferson Lines operates a bus from Rochester to Milwaukee once daily. Tickets cost $70–100 and the journey takes 5h 45m. Alternatively, Delta and American Airlines fly from Rochester (RST) to General Mitchell International Airport (MKE) every 4 hours.
- Website
- delta.com
Flights from Rochester to General Mitchell International Airport via Minneapolis–Saint Paul International Airport
- Ave. Duration
- 4h 8m
- When
- Every day
- Estimated price
- $75–480
Flights from Minneapolis–Saint Paul International Airport to General Mitchell International Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- $80–550
- Website
- aa.com
Flights from Rochester to General Mitchell International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 4h 21m
- When
- Every day
- Estimated price
- $70–470
Flights from Rochester to Chicago O'Hare International Airport
- Ave. Duration
- 1h 33m
- When
- Every day
- Estimated price
- $35–240
- Website
- suncountry.com
Flights from Minneapolis–Saint Paul International Airport to General Mitchell International Airport
- Ave. Duration
- 1h 12m
- When
- Thursday
- Estimated price
- $80–550
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Rochester to Milwaukee
- Ave. Duration
- 5h 45m
- Frequency
- Once daily
- Estimated price
- $70–100
- Book at
- Jefferson Lines
- Adult
- $70–100
Bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airport
- Ave. Duration
- 1h
- Frequency
- Every 4 hours
- Estimated price
- $40–50
- Website
- Groome Transportation - Rochester - MSP
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Chicago to Milwaukee Intermodal Station
- Ave. Duration
- 1h 20m
- Frequency
- Once daily
- Estimated price
- $13–21
- Website
- Greyhound
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