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How to get fromMayo Clinic to Milwaukeeby bus, car, or plane

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There are 5 ways to get from Mayo Clinic to Milwaukee by bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Rochester, MN to Milwaukee, WI - Amtrakbus bus Minneapolis / ...
    6h 33m
    $70–110

  2. Drive 275 mi

    cheapest
    1. Drive from Mayo Clinic to Milwaukeecar car 275 mi
    4h 32m
    $51–73

  3. Fly Rochester to General Mitchell International Airport

    1. Fly from Rochester (RST) to General Mitchell International Airport (MKE)plane plane RST - MKE
    5h 12m
    $148–823

  4. Bus to Minneapolis–Saint Paul International Airport, fly to General Mitchell International Airport

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to General Mitchell International Airport (MKE)plane plane MSP - MKE
    4h 11m
    $653–1,053

  5. Fly Rochester to Chicago O'Hare International Airport, bus

    1. Fly from Rochester (RST) to Chicago O'Hare International Airport (ORD)plane plane RST - ORD
    2. Take the bus from Multi-Modal/Rental Car Facility to Milwaukee Intermodal/Amtrak Stationbus bus
    5h 35m
    $115–570

Mayo Clinic to Milwaukee by foot and bus

Calendar21Weekly Services
Duration6h 33mAverage Duration
Ticket$70Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to Milwaukee.ExpandLaunch map view
  • Distance: 297.2 mi
  • Duration: 6h 33m

What companies run services between Mayo Clinic, MN, USA and Milwaukee, WI, USA?

Jefferson Lines operates a bus from Rochester, MN to Milwaukee, WI - Amtrak 3 times a day. Tickets cost $70–110 and the journey takes 6h 25m. Alternatively, Delta, United Airlines, and American Airlines fly from Rochester (RST) to General Mitchell International Airport (MKE) 5 times a day.

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