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How to get fromMayo Clinic to Napervilleby plane, train, bus, car, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Mayo Clinic to Naperville by plane, train, bus, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Chicago O'Hare International Airport, train

    best
    1. Fly from Rochester (RST) to Chicago O'Hare International Airport (ORD)plane plane RST - ORD
    2. Take the train from Chicago Union Station to Napervilletrain train
    5h 14m
    $77–455

  2. Drive 332.6 mi

    cheapest
    1. Drive from Mayo Clinic to Napervillecar car 332.6 mi
    5h 39m
    $61–88

  3. Bus, train via Milwaukee

    1. Take the bus from Rochester, MN to Milwaukee, WI - Amtrakbus bus
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Napervilletrain train
    10h 25m
    $106–162

  4. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Napervilletrain train
    11h 18m
    $164–315

  5. Bus to Minneapolis–Saint Paul International Airport, fly to Chicago Midway International Airport, train

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Chicago Midway International Airport (MDW)plane plane MSP - MDW
    3. Take the train from Chicago Union Station to Napervilletrain train
    6h 4m
    $112–411

  6. Bus to Minneapolis–Saint Paul International Airport, fly to Chicago O'Hare International Airport, train

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Chicago O'Hare International Airport (ORD)plane plane MSP - ORD
    3. Take the train from Chicago Union Station to Napervilletrain train
    6h 17m
    $277–461

  7. Bus, train #2

    1. Take the bus from Rochester, MN to UW-Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Napervilletrain train
    10h 43m
    $89–145

  8. Bus

    1. Take the bus from Rochester, MN to Milwaukee, WI - Amtrakbus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago to Napervillebus bus
    10h 55m

Mayo Clinic to Naperville by foot, bus, and train

Calendar21Weekly Services
Duration10h 25mAverage Duration
Ticket$106Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to Naperville.ExpandLaunch map view
  • Distance: 323.4 mi
  • Duration: 5h 14m

What companies run services between Mayo Clinic, MN, USA and Naperville, IL, USA?

You can take a vehicle from Mayo Clinic to Naperville via Rochester, MN, Milwaukee Intermodal Station, and Chicago in around 10h 55m.

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