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How to get fromMayo Clinic to Napervilleby plane, train, bus, car, or bus (Greyhound)

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There are 8 ways to get from Mayo Clinic to Naperville by plane, train, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Chicago O'Hare International Airport, train

    best
    1. Fly from Rochester (RST) to Chicago O'Hare International Airport (ORD)plane plane RST - ORD
    2. Take the train from Chicago Union Station to Napervilletrain train
    5h 12m
    $43–288

  2. Bus, train via Milwaukee

    1. Take the bus from Rochester to Milwaukeebus bus
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Napervilletrain train
    9h 46m
    $95–152

  3. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Napervilletrain train
    11h 34m
    $134–285

  4. Drive  332.6 mi

    1. Drive from Mayo Clinic to Napervillecar car 332.6 mi
    5h 40m
    $61–88

  5. Bus to Minneapolis–Saint Paul International Airport, fly to Chicago O'Hare International Airport, train

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Chicago O'Hare International Airport (ORD)plane plane MSP - ORD
    3. Take the train from Chicago Union Station to Napervilletrain train
    6h 17m
    $297–761

  6. Bus to Minneapolis–Saint Paul International Airport, fly to Chicago Midway International Airport, train

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Chicago Midway International Airport (MDW)plane plane MSP - MDW
    3. Take the train from Chicago Union Station to Napervilletrain train
    6h 12m
    $117–461

  7. Bus, train #2

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Napervilletrain train
    10h 23m
    $85–140

  8. Bus

    1. Take the bus from Rochester to Milwaukeebus bus Jefferson Lines 965
    2. Take the bus from Milwaukee Intermodal Station to Chicagobus bus Greyhound US0150
    11h 29m
    $85–121

Mayo Clinic to Naperville by foot, bus, and train

Calendar7Weekly Services
Duration9h 46mAverage Duration
Ticket$95Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mayo Clinic to Naperville.ExpandLaunch map view
  • Distance: 323 mi
  • Duration: 5h 12m

What companies run services between Mayo Clinic, MN, USA and Naperville, IL, USA?

You can take a vehicle from Mayo Clinic to Washington St & 8th St via Rochester, Milwaukee, Milwaukee Intermodal Station, Chicago, Cumberland CTA Station, Lake St & 5th Ave, and Yorktown Center in around 11h 29m.

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