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How to get fromMayo Clinic to Niagara Fallsby plane, bus, bus (Greyhound, Flixbus), train, car, or bus (Flixbus)

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There are 10 ways to get from Mayo Clinic to Niagara Falls by plane, bus, bus (Greyhound, Flixbus), train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Buffalo Niagara International Airport, bus

    best
    1. Fly from Rochester (RST) to Buffalo Niagara International Airport (BUF)plane plane RST - BUF
    2. Take the bus from Buffalo Niagara International Airport to Niagara Falls USAbus bus
    7h 28m
    $252–1,227

  2. Fly Rochester to Toronto Pearson International Airport, bus

    cheapest
    1. Fly from Rochester (RST) to Toronto Pearson International Airport (YYZ)plane plane RST - YYZ
    2. Take the bus from Toronto Union Station to Niagara Falls, ONbus bus
    10h 5m
    $137–682

  3. Bus via Cleveland

    1. Take the bus from Rochester, MN to Milwaukee, WI - Amtrakbus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus
    4. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    22h 54m
    $138–270

  4. Bus, train via Madison

    1. Take the bus from Rochester, MN to UW-Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train
    4. Take the train from Buffalo Depew Station to Canadian Bordertrain train
    23h 14m
    $265–511

  5. Drive 867.2 mi

    1. Drive from Mayo Clinic to Niagara Fallscar car 867.2 mi
    14h 25m
    $159–229

  6. Bus to Minneapolis–Saint Paul International Airport, fly to Buffalo Niagara International Airport, bus

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Buffalo Niagara International Airport (BUF)plane plane MSP - BUF
    3. Take the bus from Buffalo Niagara International Airport to Niagara Falls USAbus bus
    6h 15m
    $205–859

  7. Fly Rochester to Toronto Island Airport, bus

    1. Fly from Rochester (RST) to Toronto Island Airport (YTZ)plane plane RST - YTZ
    2. Take the bus from Toronto Union Station to Niagara Falls, ONbus bus
    9h 26m
    $140–715

  8. Bus to Minneapolis–Saint Paul International Airport, fly to Toronto Pearson International Airport, bus

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Toronto Pearson International Airport (YYZ)plane plane MSP - YYZ
    3. Take the bus from Toronto Union Station to Niagara Falls, ONbus bus
    8h 36m
    $363–1,114

  9. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train
    4. Take the train from Buffalo Depew Station to Niagara Falls Amtrak Stationtrain train
    23h 19m
    $338–809

  10. Bus

    1. Take the bus from Rochester, MN to Milwaukee, WI - Amtrakbus bus
    2. Take the bus from Milwaukee Intermodal Station to Detroit Bus Stationbus bus
    3. Take the bus from Detroit Bus Station to Torontobus bus
    4. Take the bus from Toronto Union Station to Niagara Falls, ONbus bus
    24h 58m
    $181–326

Mayo Clinic to Niagara Falls by foot and bus

Calendar21Weekly Services
Duration22h 54mAverage Duration
Ticket$138Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to Niagara Falls.ExpandLaunch map view
  • Distance: 732.9 mi
  • Duration: 7h 28m

What companies run services between Mayo Clinic, MN, USA and Niagara Falls, NY, USA?

You can take a vehicle from Mayo Clinic to Main Street & Pine Avenue via Rochester, MN, Milwaukee Intermodal Station, Chicago Bus Station, Cleveland Bus Station, Cleveland, OH, and Ellicott Street & MTC Static in around 22h 54m.

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