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How to get fromMayo Clinic to Ohioby plane, bus (Flixbus), car, or bus

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There are 9 ways to get from Mayo Clinic to Ohio by plane, bus (Flixbus), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to John Glenn Columbus International Airport

    best
    1. Fly from Rochester (RST) to John Glenn Columbus International Airport (CMH)plane plane RST - CMH
    6h 53m
    $93–590

  2. Bus

    1. Take the bus from Rochester to Milwaukeebus bus Jefferson Lines 965
    2. Take the bus from Milwaukee Intermodal Station to Columbusbus bus FlixBus 2511
    16h 43m
    $135–206

  3. Drive  655.9 mi

    1. Drive from Mayo Clinic to Columbuscar car 655.9 mi
    11h 57m
    $120–173

  4. Bus to Minneapolis–Saint Paul International Airport, fly to Cleveland-Hopkins International Airport

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Cleveland-Hopkins International Airport (CLE)plane plane MSP - CLE
    4h 51m
    $603–1,053

  5. Bus to Minneapolis–Saint Paul International Airport, fly to John Glenn Columbus International Airport

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to John Glenn Columbus International Airport (CMH)plane plane MSP - CMH
    5h 18m
    $472–1,053

  6. Fly Rochester to Covington

    1. Fly from Rochester (RST) to Covington (CVG)plane plane RST - CVG
    7h 23m
    $104–642

  7. Bus to Minneapolis–Saint Paul International Airport, fly to Covington

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Covington (CVG)plane plane MSP - CVG
    5h 42m
    $503–1,155

  8. Bus to Minneapolis–Saint Paul International Airport, fly to Detroit, bus

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Detroit (DTW)plane plane MSP - DTW
    3. Take the bus from Dearborn to Toledobus bus
    7h 26m
    $549–1,291

  9. Bus via Chicago

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago to Columbus - Mound Stbus bus
    17h 56m
    $110–214

Mayo Clinic to Ohio by foot and bus

Calendar6Weekly Services
Duration16h 43mAverage Duration
Ticket$135Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to Ohio.ExpandLaunch map view
  • Distance: 584.3 mi
  • Duration: 6h 53m

What companies run services between Mayo Clinic, MN, USA and Ohio, USA?

United Airlines, American Airlines, and Delta fly from Rochester (RST) to John Glenn Columbus International Airport (CMH) every 4 hours. Alternatively, you can take a vehicle from Mayo Clinic to Columbus via Rochester, Milwaukee, and Milwaukee Intermodal Station in around 16h 43m.

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