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How to get fromMayo Clinic to Ohioby bus, plane, bus (Flixbus), or car

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There are 8 ways to get from Mayo Clinic to Ohio by bus, plane, bus (Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Minneapolis–Saint Paul International Airport, fly to Cleveland-Hopkins International Airport

    best
    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Cleveland-Hopkins International Airport (CLE)plane plane MSP - CLE
    4h 52m
    $163–703

  2. Fly Rochester to Covington

    cheapest
    1. Fly from Rochester (RST) to Covington (CVG)plane plane RST - CVG
    6h 52m
    $104–642

  3. Bus

    1. Take the bus from Rochester to Milwaukeebus bus Jefferson Lines 965
    2. Take the bus from Milwaukee Intermodal Station to Columbusbus bus FlixBus 2511
    16h 41m
    $140–206

  4. Drive  655.9 mi

    1. Drive from Mayo Clinic to Columbuscar car 655.9 mi
    11h 57m
    $113–162

  5. Bus to Minneapolis–Saint Paul International Airport, fly to John Glenn Columbus International Airport

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to John Glenn Columbus International Airport (CMH)plane plane MSP - CMH
    5h 20m
    $162–703

  6. Bus to Minneapolis–Saint Paul International Airport, fly to Covington

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Covington (CVG)plane plane MSP - CVG
    5h 21m
    $443–1,155

  7. Bus to Minneapolis–Saint Paul International Airport, fly to Detroit, bus

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Detroit (DTW)plane plane MSP - DTW
    3. Take the bus from Dearborn to Toledobus bus
    7h 24m

  8. Bus via Chicago

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago to Columbusbus bus
    17h 55m
    $110–214

Mayo Clinic to Ohio by foot and bus

Calendar6Weekly Services
Duration16h 41mAverage Duration
Ticket$140Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mayo Clinic to Ohio.ExpandLaunch map view
  • Distance: 710.2 mi
  • Duration: 4h 52m

What companies run services between Mayo Clinic, MN, USA and Ohio, USA?

You can take a vehicle from Mayo Clinic to Columbus via Rochester, Milwaukee, and Milwaukee Intermodal Station in around 16h 41m. Alternatively, American Airlines and Delta fly from Rochester (RST) to Covington (CVG) every 4 hours.

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Bus operators

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