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How to get fromMayo Clinic to Ohioby plane, bus (Flixbus), bus, train, or car

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There are 10 ways to get from Mayo Clinic to Ohio by plane, bus (Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to John Glenn Columbus International Airport

    best
    1. Fly from Rochester (RST) to John Glenn Columbus International Airport (CMH)plane plane RST - CMH
    6h 2m
    $183–1,040

  2. Bus via Chicago

    cheapest
    1. Take the bus from Rochester, MN to UW-Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago to Columbus - Mound Stbus bus
    18h 38m
    $114–219

  3. Bus

    1. Take the bus from Rochester, MN to Milwaukee, WI - Amtrakbus bus Minneapolis / ...
    2. Take the bus from Milwaukee Intermodal Station to Columbusbus bus FlixBus 2511
    17h 23m
    $144–221

  4. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Toledotrain train
    4. Take the bus from Toledo to Columbus - Mound Stbus bus
    18h 44m
    $256–514

  5. Drive 655.9 mi

    1. Drive from Mayo Clinic to Columbuscar car 655.9 mi
    11h 57m
    $120–173

  6. Bus to Minneapolis–Saint Paul International Airport, fly to Cleveland-Hopkins International Airport

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Cleveland-Hopkins International Airport (CLE)plane plane MSP - CLE
    4h 50m
    $603–1,053

  7. Bus to Minneapolis–Saint Paul International Airport, fly to John Glenn Columbus International Airport

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to John Glenn Columbus International Airport (CMH)plane plane MSP - CMH
    5h 17m
    $462–1,053

  8. Fly Rochester to Covington

    1. Fly from Rochester (RST) to Covington (CVG)plane plane RST - CVG
    6h 23m
    $184–1,042

  9. Bus to Minneapolis–Saint Paul International Airport, fly to Covington

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Covington (CVG)plane plane MSP - CVG
    5h 41m
    $853–1,555

  10. Bus to Minneapolis–Saint Paul International Airport, fly to Detroit, bus

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Detroit (DTW)plane plane MSP - DTW
    3. Take the bus from Dearborn to Toledobus bus
    7h 29m
    $553–1,296

Mayo Clinic to Ohio by foot and bus

Calendar6Weekly Services
Duration17h 23mAverage Duration
Ticket$144Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to Ohio.ExpandLaunch map view
  • Distance: 584.3 mi
  • Duration: 6h 2m

What companies run services between Mayo Clinic, MN, USA and Ohio, USA?

Delta, United Airlines, and American Airlines fly from Rochester (RST) to John Glenn Columbus International Airport (CMH) every 4 hours. Alternatively, you can take a vehicle from Mayo Clinic to Columbus via Rochester, MN and Milwaukee Intermodal Station in around 17h 23m.

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