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How to get fromMayo Clinic to Pittsburghby plane, bus, train, bus (Greyhound, Flixbus), car, or bus (Flixbus)

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There are 7 ways to get from Mayo Clinic to Pittsburgh by plane, bus, train, bus (Greyhound, Flixbus), car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Rochester

    best
    1. Fly from Rochester (RST) to Pittsburgh International Airport (PIT)plane plane RST - PIT
    7h 6m
    $86–517

  2. Bus, train via Madison

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Pittsburgh Amtrak Stationtrain train
    19h 24m
    $200–414

  3. Bus via Milwaukee

    1. Take the bus from Rochester to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Pittsburgh Intermodal Stationbus bus
    19h 53m
    $153–238

  4. Drive  806.3 mi

    1. Drive from Mayo Clinic to Pittsburghcar car 806.3 mi
    13h 16m
    $148–213

  5. Bus to Minneapolis–Saint Paul International Airport, fly

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Pittsburgh International Airport (PIT)plane plane MSP - PIT
    5h 51m
    $550–1,050

  6. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Pittsburgh Amtrak Stationtrain train
    20h 35m
    $249–559

  7. Bus

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago to Pittsburgh Intermodal Stationbus bus
    21h 13m
    $165–262

Mayo Clinic to Pittsburgh by foot, bus, and train

Calendar7Weekly Services
Duration19h 24mAverage Duration
Ticket$200Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to Pittsburgh.ExpandLaunch map view
  • Distance: 702.5 mi
  • Duration: 7h 6m

What companies run services between Mayo Clinic, MN, USA and Pittsburgh, PA, USA?

Delta, United Airlines, and American Airlines fly from Rochester (RST) to Pittsburgh International Airport (PIT) every 4 hours. Alternatively, you can take a vehicle from Mayo Clinic to Pittsburgh Intermodal Station via Rochester, Milwaukee, Milwaukee Intermodal Station, and Chicago Bus Station in around 19h 53m.

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