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How to get fromMayo Clinic to Rochesterby plane, bus, train, bus (Greyhound, Flixbus), or car

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There are 7 ways to get from Mayo Clinic to Rochester by plane, bus, train, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Rochester

    best
    1. Fly from Rochester (RST) to Rochester (ROC)plane plane RST - ROC
    5h 44m
    $280–1,339

  2. Drive 941.7 mi

    cheapest
    1. Drive from Mayo Clinic to Rochestercar car 941.7 mi
    16h 4m
    $172–249

  3. Bus, train via Madison

    1. Take the bus from Rochester, MN to UW-Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Rochestertrain train
    21h 49m
    $274–529

  4. Bus

    1. Take the bus from Rochester, MN to Milwaukee, WI - Amtrakbus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus
    4. Take the bus from Cleveland Bus Station to Rochester Bus Stopbus bus
    23h 40m
    $178–324

  5. Bus to Minneapolis–Saint Paul International Airport, fly to Rochester

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Rochester (ROC)plane plane MSP - ROC
    6h 40m
    $225–869

  6. Bus to Minneapolis–Saint Paul International Airport, fly to Buffalo Niagara International Airport, bus

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Buffalo Niagara International Airport (BUF)plane plane MSP - BUF
    3. Take the bus from Buffalo Niagara International Airport to Rochester Bus Stopbus bus
    6h 22m
    $226–890

  7. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Rochestertrain train
    22h 25m
    $349–699

Mayo Clinic to Rochester by foot, bus, and train

Calendar14Weekly Services
Duration21h 49mAverage Duration
Ticket$274Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to Rochester.ExpandLaunch map view
  • Distance: 756.3 mi
  • Duration: 5h 44m

What companies run services between Mayo Clinic, MN, USA and Rochester, NY, USA?

United Airlines, American Airlines, and Delta fly from Rochester (RST) to Rochester (ROC) 4 times a day. Alternatively, you can take a vehicle from Mayo Clinic to Rochester Bus Stop via Rochester, MN, Milwaukee Intermodal Station, Chicago Bus Station, and Cleveland Bus Station in around 23h 40m.

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