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How to get fromMayo Clinic to Royal Oakby plane, bus (Flixbus), bus, train, car, or bus (Amtrak)

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There are 8 ways to get from Mayo Clinic to Royal Oak by plane, bus (Flixbus), bus, train, car, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Detroit

    best
    1. Fly from Rochester (RST) to Detroit (DTW)plane plane RST - DTW
    8h 21m
    $89–503

  2. Bus

    1. Take the bus from Rochester, MN to Milwaukee, WI - Amtrakbus bus Minneapolis / ...
    2. Take the bus from Milwaukee Intermodal Station to Detroit Bus Stationbus bus FlixBus 2550
    16h 9m
    $136–213

  3. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Royal Oak Amtraktrain train
    16h 39m
    $249–509

  4. Drive 627.2 mi

    1. Drive from Mayo Clinic to Royal Oakcar car 627.2 mi
    10h 27m
    $115–166

  5. Bus to Minneapolis–Saint Paul International Airport, fly to Detroit

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Detroit (DTW)plane plane MSP - DTW
    6h 51m
    $528–1,266

  6. Fly Rochester to Bishop International Airport, bus

    1. Fly from Rochester (RST) to Bishop International Airport (FNT)plane plane RST - FNT
    2. Take the bus from Flint Amtrak to Pontiac Amtrakbus bus
    8h 59m
    $107–452

  7. Bus via Chicago

    1. Take the bus from Rochester, MN to UW-Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago Union Station to Royal Oak Amtrakbus bus
    16h 25m
    $179–279

  8. Bus, train via Madison

    1. Take the bus from Rochester, MN to UW-Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Royal Oak Amtraktrain train
    16h 25m
    $174–339

Mayo Clinic to Royal Oak by foot and bus

Calendar4Weekly Services
Duration16h 9mAverage Duration
Ticket$136Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to Royal Oak.ExpandLaunch map view
  • Distance: 517.1 mi
  • Duration: 8h 21m

What companies run services between Mayo Clinic, MN, USA and Royal Oak, MI, USA?

American Airlines, United Airlines, and Delta fly from Rochester (RST) to Detroit (DTW) every 4 hours. Alternatively, you can take a vehicle from Mayo Clinic to Woodward & Hendrie via Rochester, MN, Milwaukee Intermodal Station, Detroit Bus Station, and Jefferson & Griswold in around 16h 9m.

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