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How to get fromMayo Clinic to San Diegoby plane, bus, train, bus (Greyhound, Amtrak), or car

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There are 5 ways to get from Mayo Clinic to San Diego by plane, bus, train, bus (Greyhound, Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Rochester

    best
    1. Fly from Rochester (RST) to San Diego International Airport (SAN)plane plane RST - SAN
    6h 55m
    $141–687

  2. Bus, train

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain train
    4. Take the train from Fullerton Amtrak Station to San Diegotrain train
    2d 8h
    $810–1,704

  3. Bus

    1. Take the bus from Rochester to Minneapolisbus bus
    2. Take the bus from Minneapolis to Tulsabus bus
    3. Take the bus from Tulsa Bus Station to Los Angeles Union Stationbus bus
    4. Take the bus from Los Angeles to San Diegobus bus
    2d 9h
    $441–752

  4. Drive 1,905.3 mi

    1. Drive from Mayo Clinic to San Diegocar car 1,905.3 mi
    30h 57m
    $348–503

  5. Bus to Minneapolis–Saint Paul International Airport, fly

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to San Diego International Airport (SAN)plane plane MSP - SAN
    6h 8m
    $260–600

Mayo Clinic to San Diego by foot, bus, and train

Calendar7Weekly Services
Duration2d 8hAverage Duration
Ticket$810Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to San Diego.ExpandLaunch map view
  • Distance: 1,545.9 mi
  • Duration: 6h 55m

What companies run services between Mayo Clinic, MN, USA and San Diego, CA, USA?

Delta, American Airlines, and United Airlines fly from Rochester (RST) to San Diego International Airport (SAN) every 4 hours. Alternatively, you can take a vehicle from Mayo Clinic to San Diego via Rochester, Minneapolis, Tulsa Bus Station, Los Angeles Union Station, and Los Angeles in around 2d 9h.

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