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How to get fromMayo Clinic to Sioux Cityby shuttle, bus, car, or plane

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There are 7 ways to get from Mayo Clinic to Sioux City by shuttle, bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Shuttle, bus

    best
    1. Take a shuttle bus from Rochester to Owatonna, MNshuttle bus
    2. Take the bus from Owatonna to Albert Leabus bus
    3. Take the bus from Albert Lea to Sioux Fallsbus bus
    4. Take the bus from Sioux Falls to Sioux Citybus bus
    9h 42m
    $100–184

  2. Drive 269.9 mi

    cheapest
    1. Drive from Mayo Clinic to Sioux Citycar car 269.9 mi
    4h 40m
    $50–72

  3. Fly Rochester to Sioux Gateway Airport/Col. Bud Day Field

    1. Fly from Rochester (RST) to Sioux Gateway Airport/Col. Bud Day Field (SUX)plane plane RST - SUX
    7h 57m
    $97–453

  4. Bus via Burnsville

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Take the bus from Burnsville to Sioux Fallsbus bus
    3. Take the bus from Sioux Falls to Sioux Citybus bus
    11h 27m
    $147–199

  5. Bus

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Take the bus from Minneapolis-St. Paul to Sioux Fallsbus bus
    3. Take the bus from Sioux Falls to Sioux Citybus bus
    12h 22m
    $155–210

  6. Fly Rochester to Sioux Falls, bus

    1. Fly from Rochester (RST) to Sioux Falls (FSD)plane plane RST - FSD
    2. Take the bus from Sioux Falls to Sioux Citybus bus
    7h 25m
    $86–400

  7. Bus to Minneapolis–Saint Paul International Airport, fly to Sioux Falls, bus

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Sioux Falls (FSD)plane plane MSP - FSD
    3. Take the bus from Sioux Falls to Sioux Citybus bus
    6h 26m
    $135–443

Rochester (RST) to Sioux Gateway Airport/Col. Bud Day Field (SUX) flights

Calendar26Weekly Planes
Duration10h 7mAverage Duration
Ticket$75Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to Sioux City.ExpandLaunch map view
  • Distance: 350.2 mi
  • Duration: 9h 42m

What companies run services between Mayo Clinic, MN, USA and Sioux City, IA, USA?

United Airlines and American Airlines fly from Rochester (RST) to Sioux Gateway Airport/Col. Bud Day Field (SUX) 4 times a day. Alternatively, you can take a vehicle from Mayo Clinic to Sioux City via Groome Transportation Office - Rochester, Minneapolis / St Paul Airport, MSP Terminal 1 Transit Station, Burnsville, and Sioux Falls in around 11h 27m.

Airlines
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