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How to get fromMayo Clinic to Sioux Fallsby shuttle, bus, car, or plane

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There are 6 ways to get from Mayo Clinic to Sioux Falls by shuttle, bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Shuttle, bus

    best
    1. Take a shuttle bus from Rochester to Owatonna, MNshuttle bus
    2. Take the bus from Owatonna to Albert Leabus bus
    3. Take the bus from Albert Lea to Sioux Fallsbus bus
    6h 57m
    $83–151

  2. Drive 234.2 mi

    cheapest
    1. Drive from Mayo Clinic to Sioux Fallscar car 234.2 mi
    3h 51m
    $43–62

  3. Fly from Rochester

    1. Fly from Rochester (RST) to Sioux Falls (FSD)plane plane RST - FSD
    5h 42m
    $48–339

  4. Bus via Burnsville

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus Groome Transportation
    2. Take the bus from Burnsville to Sioux Fallsbus bus Jefferson 701
    10h 10m
    $119–151

  5. Bus

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus Groome Transportation
    2. Take the bus from Minneapolis-St. Paul to Sioux Fallsbus bus Jefferson Lines 925
    11h 5m
    $127–162

  6. Bus to Minneapolis–Saint Paul International Airport, fly

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Sioux Falls (FSD)plane plane MSP - FSD
    4h 43m
    $97–382

Rochester (RST) to Sioux Falls (FSD) flights

Calendar55Weekly Planes
Duration5h 11mAverage Duration
Ticket$46Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to Sioux Falls.ExpandLaunch map view
  • Distance: 257.5 mi
  • Duration: 6h 57m

What companies run services between Mayo Clinic, MN, USA and Sioux Falls, SD, USA?

Delta, American Airlines, and United Airlines fly from Rochester (RST) to Sioux Falls (FSD) every 4 hours. Alternatively, you can take a vehicle from Mayo Clinic to The Bus Stop via Groome Transportation Office - Rochester, Minneapolis / St Paul Airport, MSP Terminal 1 Transit Station, Burnsville, Sioux Falls, and Maple/Career NE corner in around 10h 10m.

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