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How to get fromMayo Clinic to Springfieldby plane, bus, train, car, or bus (Greyhound, Flixbus)

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There are 6 ways to get from Mayo Clinic to Springfield by plane, bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Abraham Lincoln Capital Airport

    best
    1. Fly from Rochester (RST) to Abraham Lincoln Capital Airport (SPI)plane plane RST - SPI
    6h 31m
    $70–404

  2. Bus, train via Madison

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Springfieldtrain train
    12h 54m
    $125–244

  3. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Springfieldtrain train
    14h 5m
    $174–389

  4. Drive  396.1 mi

    1. Drive from Mayo Clinic to Springfieldcar car 396.1 mi
    7h 50m
    $73–105

  5. Fly to Decatur Airport, bus

    1. Fly from Rochester (RST) to Decatur Airport (DEC)plane plane RST - DEC
    2. Take the bus from Decatur Downtown Transportation Center to Springfield SMTD Transfer Centerbus bus
    9h 37m
    $75–403

  6. Bus

    1. Take the bus from Rochester to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Springfield SMTD Transfer Centerbus bus
    13h 33m
    $113–168

Mayo Clinic to Springfield by foot, bus, and train

Calendar7Weekly Services
Duration12h 54mAverage Duration
Ticket$125Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mayo Clinic to Springfield.ExpandLaunch map view
  • Distance: 329.1 mi
  • Duration: 6h 31m

What companies run services between Mayo Clinic, MN, USA and Springfield, IL, USA?

American Airlines flies from Rochester (RST) to Abraham Lincoln Capital Airport (SPI) twice daily. Alternatively, you can take a vehicle from Mayo Clinic to Springfield SMTD Transfer Center via Rochester, Milwaukee, Milwaukee Intermodal Station, and Chicago Bus Station in around 13h 33m.

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