Rome2Rio

How to get fromMayo Clinic to Springfieldby plane, bus, train, car, bus (Greyhound, Flixbus), or bus (Greyhound, Amtrak)

Find Transport to Springfield

See all options

There are 7 ways to get from Mayo Clinic to Springfield by plane, bus, train, car, bus (Greyhound, Flixbus), or bus (Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Abraham Lincoln Capital Airport

    best
    1. Fly from Rochester (RST) to Abraham Lincoln Capital Airport (SPI)plane plane RST - SPI
    5h 18m
    $129–687

  2. Drive 396.1 mi

    cheapest
    1. Drive from Mayo Clinic to Springfieldcar car 396.1 mi
    7h 50m
    $73–105

  3. Bus, train via Madison

    1. Take the bus from Rochester, MN to UW-Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Springfieldtrain train
    13h 14m
    $144–269

  4. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Springfieldtrain train
    13h 50m
    $219–439

  5. Fly to Decatur Airport, bus

    1. Fly from Rochester (RST) to Decatur Airport (DEC)plane plane RST - DEC
    2. Take the bus from Decatur Downtown Transportation Center to Springfield SMTD Transfer Centerbus bus
    9h 45m
    $135–698

  6. Bus via Milwaukee

    1. Take the bus from Rochester, MN to Milwaukee, WI - Amtrakbus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Springfield SMTD Transfer Centerbus bus
    14h 25m
    $123–189

  7. Bus

    1. Take the bus from Rochester to Albert Leabus bus
    2. Take the bus from Albert Lea to Des Moinesbus bus
    3. Take the bus from Des Moines to Galesburgbus bus
    4. Take the bus from Galesburg Amtrak Station to Springfieldbus bus
    14h 48m
    $141–226

Mayo Clinic to Springfield by foot, bus, and train

Calendar21Weekly Services
Duration13h 14mAverage Duration
Ticket$144Cheapest Price
See schedules

Questions & Answers

Map of how to get from Mayo Clinic to Springfield.ExpandLaunch map view
  • Distance: 329.1 mi
  • Duration: 5h 18m

What companies run services between Mayo Clinic, MN, USA and Springfield, IL, USA?

American Airlines flies from Rochester (RST) to Abraham Lincoln Capital Airport (SPI) 3 times a day. Alternatively, you can take a vehicle from Mayo Clinic to Springfield SMTD Transfer Center via Rochester, MN, Milwaukee Intermodal Station, and Chicago Bus Station in around 14h 25m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers