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How to get fromMayo Clinic to Springfieldby bus, train, car, plane, or bus (Greyhound, Flixbus)

Find Transport to Springfield

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There are 5 ways to get from Mayo Clinic to Springfield by bus, train, car, plane, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train via Madison

    best
    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Springfieldtrain train
    12h 54m
    $180–294

  2. Fly

    cheapest
    1. Fly from Rochester (RST) to Abraham Lincoln Capital Airport (SPI)plane plane RST - SPI
    8h 53m
    $70–404

  3. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Springfieldtrain train
    14h 5m
    $349–549

  4. Drive  396.1 mi

    1. Drive from Mayo Clinic to Springfieldcar car 396.1 mi
    7h 50m
    $73–105

  5. Bus

    1. Take the bus from Rochester to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Springfield SMTD Transfer Centerbus bus
    13h 33m
    $113–169

Mayo Clinic to Springfield by foot, bus, and train

Calendar7Weekly Services
Duration12h 54mAverage Duration
Ticket$180Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mayo Clinic to Springfield.ExpandLaunch map view
  • Distance: 542.7 mi
  • Duration: 12h 54m

What companies run services between Mayo Clinic, MN, USA and Springfield, IL, USA?

American Airlines flies from Rochester (RST) to Abraham Lincoln Capital Airport (SPI) 3 times a day. Alternatively, you can take a vehicle from Mayo Clinic to Springfield SMTD Transfer Center via Rochester, Milwaukee, Milwaukee Intermodal Station, and Chicago Bus Station in around 13h 33m.

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