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How to get fromMayo Clinic to St. Louisby plane, bus, train, car, or bus (Greyhound, Flixbus)

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There are 6 ways to get from Mayo Clinic to St. Louis by plane, bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Rochester

    best
    1. Fly from Rochester (RST) to Lambert–St. Louis International Airport (STL)plane plane RST - STL
    6h 19m
    $89–540

  2. Drive  448.5 mi

    cheapest
    1. Drive from Mayo Clinic to St. Louiscar car 448.5 mi
    8h 13m
    $82–119

  3. Bus, train via Madison

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to St. Louistrain train
    14h 45m
    $145–294

  4. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    15h 56m
    $194–439

  5. Bus to Minneapolis–Saint Paul International Airport, fly

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Lambert–St. Louis International Airport (STL)plane plane MSP - STL
    4h 33m
    $433–1,003

  6. Bus

    1. Take the bus from Rochester to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus
    15h 23m
    $128–193

Mayo Clinic to St. Louis by foot, bus, and train

Calendar7Weekly Services
Duration14h 45mAverage Duration
Ticket$145Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mayo Clinic to St. Louis.ExpandLaunch map view
  • Distance: 396.3 mi
  • Duration: 6h 19m

What companies run services between Mayo Clinic, MN, USA and St. Louis, MO, USA?

United Airlines, American Airlines, and Delta fly from Rochester (RST) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a vehicle from Mayo Clinic to St Louis Bus Station via Rochester, Milwaukee, Milwaukee Intermodal Station, and Chicago Bus Station in around 15h 23m.

Airlines
Train operators
Bus operators

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