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How to get fromMayo Clinic to St. Louisby plane, bus (Greyhound), bus, train, or car

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There are 7 ways to get from Mayo Clinic to St. Louis by plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Rochester

    best
    1. Fly from Rochester (RST) to Lambert–St. Louis International Airport (STL)plane plane RST - STL
    6h 7m
    $188–973

  2. Drive 448.5 mi

    cheapest
    1. Drive from Mayo Clinic to St. Louiscar car 448.5 mi
    8h 13m
    $82–119

  3. Bus

    1. Take the bus from Rochester to Owatonnabus bus
    2. Take the bus from Owatonna to Des Moinesbus bus
    3. Take the bus from Des Moines to St Louis Bus Stationbus bus
    14h 53m
    $136–229

  4. Bus, train

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    15h 41m
    $249–499

  5. Bus to Minneapolis–Saint Paul International Airport, fly

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Lambert–St. Louis International Airport (STL)plane plane MSP - STL
    4h 31m
    $433–1,003

  6. Bus, train via Madison

    1. Take the bus from Rochester, MN to UW-Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to St. Louistrain train
    15h 5m
    $174–329

  7. Bus via Albert Lea

    1. Take the bus from Rochester to Albert Leabus bus
    2. Take the bus from Albert Lea to Des Moinesbus bus
    3. Take the bus from Des Moines to St Louis Bus Stationbus bus
    15h 23m
    $136–231

Mayo Clinic to St. Louis by foot, bus, and train

Calendar21Weekly Services
Duration15h 5mAverage Duration
Ticket$174Cheapest Price
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Questions & Answers

Map of how to get from Mayo Clinic to St. Louis.ExpandLaunch map view
  • Distance: 396.3 mi
  • Duration: 6h 7m

What companies run services between Mayo Clinic, MN, USA and St. Louis, MO, USA?

United Airlines, American Airlines, and Delta fly from Rochester (RST) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a vehicle from Mayo Clinic to St Louis Bus Station via Rochester, Owatonna, and Des Moines in around 14h 53m.

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