Rome2Rio

How to get fromMayo Clinic to Waterlooby shuttle, bus, car, or bus (Greyhound)

Find Transport to Waterloo

See all options

There are 3 ways to get from Mayo Clinic to Waterloo by shuttle, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Shuttle, bus

    best
    1. Take a shuttle bus from Rochester to Owatonna, MNshuttle bus
    2. Take the bus from Owatonna to Des Moinesbus bus
    3. Take the bus from Des Moines to Waterloobus bus
    9h 32m
    $74–147
  2. Drive 113.2 mi

    cheapest
    1. Drive from Mayo Clinic to Waterloocar car 113.2 mi
    2h 17m
    $21–30
  3. Bus

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Take the bus from MSP Airport to Des Moinesbus bus
    3. Take the bus from Des Moines to Waterloobus bus
    12h
    $133–180

Questions & Answers

What companies run services between Mayo Clinic, MN, USA and Waterloo, IA, USA?

You can take a vehicle from Mayo Clinic to Waterloo via Groome Transportation Office - Rochester, Minneapolis / St Paul Airport, MSP Airport, and Des Moines in around 12h.

Operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound