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How to get fromMcHenry to Mayo Clinicby train, plane, bus, or car

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There are 7 ways to get from McHenry to Mayo Clinic by train, plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Chicago O'Hare International Airport, fly to Rochester

    best
    1. Take the train from McHenry to Des Plainestrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    5h 18m
    $47–339

  2. Train, bus via Madison

    1. Take the train from McHenry to Des Plainestrain train
    2. Take the bus from Multi-Modal/Rental Car Facility to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    10h 23m
    $79–134

  3. Train, bus

    1. Take the train from McHenry to Chicago OTCtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochester, MNbus bus
    12h 35m
    $168–321

  4. Drive 292.5 mi

    1. Drive from McHenry to Mayo Cliniccar car 292.5 mi
    5h 5m
    $54–78

  5. Train to Chicago O'Hare International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from McHenry to Des Plainestrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Minneapolis–Saint Paul International Airport (MSP)plane plane ORD - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 1m
    $278–511

  6. Train to Chicago Midway International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from McHenry to Chicago OTCtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Minneapolis–Saint Paul International Airport (MSP)plane plane MDW - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 43m
    $136–545

  7. Train, bus #2

    1. Take the train from Fox Lake to Glenviewtrain train
    2. Take the train from Glenview Amtrak Station to Milwaukeetrain train
    3. Take the bus from Milwaukee to Rochesterbus bus
    11h 7m
    $99–155

McHenry to Mayo Clinic by train, bus, and foot

Calendar15Weekly Services
Duration12h 35mAverage Duration
Ticket$168Cheapest Price
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Questions & Answers

Map of how to get from McHenry to Mayo Clinic.ExpandLaunch map view
  • Distance: 318.3 mi
  • Duration: 5h 18m

What companies run services between McHenry, IL, USA and Mayo Clinic, MN, USA?

There is no direct connection from McHenry to Mayo Clinic. However, you can take the train to Des Plaines, walk to Des Plaines Metra Station, take the bus to O'Hare MMF Bay 9, walk to Multi-Modal Facility, take the train to Terminal 2, walk to Chicago O'Hare International Airport (ORD) airport, fly to Rochester (RST), walk to Rochester - Airport, take the shuttle to Rochester, then walk to Mayo Clinic. Alternatively, you can take a train from McHenry to Mayo Clinic via Des Plaines, Des Plaines Metra Station, Multi-Modal/Rental Car Facility, Madison, and Rochester in around 10h 23m.

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