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How to get fromMebane to Knoxvilleby bus, plane, shuttle, car, or train

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There are 5 ways to get from Mebane to Knoxville by bus, plane, shuttle, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Raleigh-Durham International Airport, fly

    best
    1. Take the bus from E Washington St at S 5th St to Willard St at Durham Stationbus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Mcghee Tyson Airport (TYS)plane plane RDU - TYS
    6h 56m
    $156–728

  2. Drive 296.4 mi

    cheapest
    1. Drive from Mebane to Knoxvillecar car 296.4 mi
    5h 54m
    $55–79

  3. Bus, shuttle, drive

    1. Take the bus from E Washington St at S 5th St to Willard St at Durham Stationbus bus Odx
    2. Take the bus from Durham to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Airport to ASU Peacock Hall Boonebus bus
    4. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Knoxvillecar car
    13h 19m
    $380–440

  4. Bus to Piedmont Triad International Airport, fly

    1. Take the bus from Mebane Cone Health Park & Ride to Coble Transportation Centerbus bus
    2. Fly from Piedmont Triad International Airport (GSO) to Mcghee Tyson Airport (TYS)plane plane GSO - TYS
    7h 15m
    $186–844

  5. Bus, train to Charlotte Douglas International Airport, fly

    1. Take the bus from E Washington St at S 5th St to Willard St at Durham Stationbus bus
    2. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    3. Fly from Charlotte Douglas International Airport (CLT) to Mcghee Tyson Airport (TYS)plane plane CLT - TYS
    8h 16m
    $198–828

Raleigh-Durham International Airport (RDU) to Mcghee Tyson Airport (TYS) flights

Calendar130Weekly Planes
Duration3h 55mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

Map of how to get from Mebane to Knoxville.ExpandLaunch map view
  • Distance: 348.6 mi
  • Duration: 6h 56m

What companies run services between Mebane, NC, USA and Knoxville, TN, USA?

There is no direct connection from Mebane to Knoxville. However, you can take the bus to Willard St at Durham Station, walk to Durham Station, take the bus to Regional Transit Center, take the line 100 bus to RDU Airport at Terminal 1, walk to Raleigh-Durham-Airport-RDU airport, fly to Mcghee Tyson Airport (TYS), then take the taxi to Knoxville. Alternatively, you can take a bus from E Washington St at S 5th St to Knoxville via Durham, Charlotte Bus Station, Charlotte Airport, ASU Peacock Hall Boone, Boone, Black Bear Resort, and Hot Springs in around 13h 19m.

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