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How to get fromMechanicsburg to Buffaloby bus, car, train, or plane

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There are 4 ways to get from Mechanicsburg to Buffalo by bus, car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Harrisburg, Pa to Dubois, Pabus bus 731
    2. Take the bus from DuBois to Buffalobus bus Fab510 / ...
    11h 57m
    $58–202

  2. Drive 288.7 mi

    cheapest
    1. Drive from Mechanicsburg to Buffalocar car 288.7 mi
    5h 45m
    $53–77

  3. Train to Philadelphia International Airport, fly

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Buffalo Niagara International Airport (BUF)plane plane PHL - BUF
    7h 17m
    $145–804

  4. Train, train to Baltimore-Washington International Airport, fly

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    3. Fly from Baltimore-Washington International Airport (BWI) to Buffalo Niagara International Airport (BUF)plane plane BWI - BUF
    8h 15m
    $146–1,351

Mechanicsburg to Buffalo by bus and foot

Calendar1Weekly Services
Duration11h 57mAverage Duration
Ticket$58Cheapest Price
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Questions & Answers

Map of how to get from Mechanicsburg to Buffalo.ExpandLaunch map view
  • Distance: 341 mi
  • Duration: 11h 57m

What companies run services between Mechanicsburg, Cumberland County, PA, USA and Buffalo, NY, USA?

You can take a bus from E Main St & Arch St EB to Buffalo via Market Square Transfer Center, Harrisburg, Pa, and DuBois in around 11h 57m.

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