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How to get fromMechanicsburg to Charlestonby plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus

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There are 6 ways to get from Mechanicsburg to Charleston by plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Harrisburg International Airport to Charleston International Airport

    best
    1. Fly from Harrisburg International Airport (MDT) to Charleston International Airport (CHS)plane plane MDT - CHS
    7h 45m
    $144–806

  2. Bus

    cheapest
    1. Take the bus from Harrisburg Bus Station to Baltimore Downtown Bus Stationbus bus
    2. Take the bus from Baltimore Downtown Bus Station to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Charleston Bus Stationbus bus
    20h 40m
    $111–214

  3. Train (Amtrak)

    1. Take the train from Harrisburg to 30th Street Stationtrain train Keystone Service / ...
    2. Take the train from 30th Street Station to Charleston Amtrak Stationtrain train Silver Meteor / ...
    17h
    $261–532

  4. Drive 603.5 mi

    1. Drive from Mechanicsburg to Charlestoncar car 603.5 mi
    11h 24m
    $111–160

  5. Train to Philadelphia International Airport, fly to Charleston International Airport

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Charleston International Airport (CHS)plane plane PHL - CHS
    8h 24m
    $366–977

  6. Fly Harrisburg International Airport to Myrtle Beach, bus

    1. Fly from Harrisburg International Airport (MDT) to Myrtle Beach (MYR)plane plane MDT - MYR
    2. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    9h 14m
    $131–701

Mechanicsburg to Charleston by bus and foot

Calendar14Weekly Services
Duration20h 40mAverage Duration
Ticket$111Cheapest Price
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Questions & Answers

Map of how to get from Mechanicsburg to Charleston.ExpandLaunch map view
  • Distance: 569.4 mi
  • Duration: 7h 45m

What companies run services between Mechanicsburg, Cumberland County, PA, USA and Charleston, SC, USA?

United Airlines, American Airlines, and Delta fly from Harrisburg International Airport (MDT) to Charleston International Airport (CHS) hourly. Alternatively, you can take a bus from E Main St & Race St EB to Charleston via Market Square Transfer Center, Harrisburg, 30th Street Station, and Charleston Amtrak Station in around 17h.

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