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How to get fromMechanicsburg to Chicagoby bus, plane, train (Amtrak), bus (Flixbus), car, or bus (Greyhound)

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There are 6 ways to get from Mechanicsburg to Chicago by bus, plane, train (Amtrak), bus (Flixbus), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Harrisburg International Airport, fly

    best
    1. Take the bus from E Main St & Race St EB to Market Square Transfer Centerbus bus
    2. Fly from Harrisburg International Airport (MDT) to Chicago O'Hare International Airport (ORD)plane plane MDT - ORD
    5h 16m
    $54–309

  2. Train (Amtrak)

    1. Take the train from Harrisburg to Pittsburgh Amtrak Stationtrain train Pennsylvanian
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    17h 46m
    $181–422

  3. Bus (Flixbus)

    1. Take the bus from Harrisburg Bus Station to Chicago Bus Stationbus bus FlixBus N2640 / ...
    18h 2m
    $111–182

  4. Drive  648.5 mi

    1. Drive from Mechanicsburg to Chicagocar car 648.5 mi
    10h 43m
    $119–171

  5. Bus to Penn State University Park Airport, fly

    1. Take the bus from Harrisburg Bus Station to State College Regional Airportbus bus
    2. Fly from Penn State University Park Airport (SCE) to Chicago O'Hare International Airport (ORD)plane plane SCE - ORD
    6h 55m
    $66–318

  6. Bus via Baltimore (Greyhound)

    1. Take the bus from Harrisburg Bus Station to Baltimore Downtown Bus Stationbus bus Greyhound US0430
    2. Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    23h 2m
    $123–211

Mechanicsburg to Chicago by bus, foot, and train (Amtrak)

Calendar7Weekly Services
Duration17h 46mAverage Duration
Ticket$181Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mechanicsburg to Chicago.ExpandLaunch map view
  • Distance: 629.1 mi
  • Duration: 5h 16m

What companies run services between Mechanicsburg, Cumberland County, PA, USA and Chicago, IL, USA?

You can take a bus from E Main St & Race St EB to Chicago Union Station via Market Square Transfer Center, Harrisburg, and Pittsburgh Amtrak Station in around 17h 46m. Alternatively, Flixbus USA operates a bus from Harrisburg Bus Station to Chicago Bus Station once daily. Tickets cost $110–180 and the journey takes 16h 30m.

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