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How to get fromMechanicsburg to Chicagoby bus, plane, train (Amtrak), bus (Flixbus), car, train, or bus (Greyhound)

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There are 7 ways to get from Mechanicsburg to Chicago by bus, plane, train (Amtrak), bus (Flixbus), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Harrisburg International Airport, fly

    best
    1. Take the bus from E Main St & Race St EB to Market Square Transfer Centerbus bus
    2. Fly from Harrisburg International Airport (MDT) to Chicago O'Hare International Airport (ORD)plane plane MDT - ORD
    5h 18m
    $114–659

  2. Bus to Penn State University Park Airport, fly

    cheapest
    1. Take the bus from Harrisburg Bus Station to State College Regional Airportbus bus
    2. Fly from Penn State University Park Airport (SCE) to Chicago O'Hare International Airport (ORD)plane plane SCE - ORD
    6h 56m
    $83–332

  3. Train (Amtrak)

    1. Take the train from Harrisburg to Pittsburgh Amtrak Stationtrain train Pennsylvanian
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    17h 46m
    $226–482

  4. Bus

    1. Take the bus from Harrisburg Bus Station to Chicago Bus Stationbus bus FlixBus N2640 / ...
    18h 2m
    $171–242

  5. Drive 648.5 mi

    1. Drive from Mechanicsburg to Chicagocar car 648.5 mi
    10h 43m
    $119–171

  6. Train, line 18 bus, line 10 bus to Lancaster, fly

    1. Take the train from Harrisburg to Elizabethtown Amtrak Stationtrain train
    2. Take the bus from AMTRAK ETown to Queen St. Stationbus bus
    3. Take the bus from Queen St. Station to 501 & Airport Rd.bus bus
    4. Fly from Lancaster (LNS) to Chicago O'Hare International Airport (ORD)plane plane LNS - ORD
    7h 36m

  7. Bus via Baltimore

    1. Take the bus from Harrisburg Bus Station to Baltimore Downtown Bus Stationbus bus Greyhound US0430
    2. Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    22h 57m
    $189–272

Mechanicsburg to Chicago by bus, foot, and train (Amtrak)

Calendar7Weekly Services
Duration17h 46mAverage Duration
Ticket$226Cheapest Price
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Questions & Answers

Map of how to get from Mechanicsburg to Chicago.ExpandLaunch map view
  • Distance: 629.1 mi
  • Duration: 5h 18m

What companies run services between Mechanicsburg, Cumberland County, PA, USA and Chicago, IL, USA?

You can take a bus from E Main St & Race St EB to Chicago Union Station via Market Square Transfer Center, Harrisburg, and Pittsburgh Amtrak Station in around 17h 46m. Alternatively, Flixbus USA operates a bus from Harrisburg Bus Station to Chicago Bus Station once daily. Tickets cost $120–210 and the journey takes 16h 30m. Jefferson Lines also services this route once daily.

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