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How to get fromMechanicsburg to Detroitby bus, plane, bus (Greyhound), train, or car

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There are 4 ways to get from Mechanicsburg to Detroit by bus, plane, bus (Greyhound), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, fly

    best
    1. Take the bus from E Main St & Race St EB to Market Square Transfer Centerbus bus
    2. Fly from Harrisburg International Airport (MDT) to Detroit (DTW)plane plane MDT - DTW
    5h 21m
    $144–856

  2. Bus

    cheapest
    1. Take the bus from Harrisburg Bus Station to Detroit Bus Stationbus bus Greyhound US0420
    14h 22m
    $81–162

  3. Train, bus

    1. Take the train from Harrisburg to Pittsburgh Amtrak Stationtrain train
    2. Take the train from Pittsburgh Amtrak Station to Toledotrain train
    3. Take the bus from Toledo to Detroitbus bus
    15h 9m
    $161–362

  4. Drive 473.8 mi

    1. Drive from Mechanicsburg to Detroitcar car 473.8 mi
    7h 51m
    $87–125

Mechanicsburg to Detroit by bus and foot

Calendar14Weekly Services
Duration14h 22mAverage Duration
Ticket$81Cheapest Price
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Questions & Answers

Map of how to get from Mechanicsburg to Detroit.ExpandLaunch map view
  • Distance: 410.8 mi
  • Duration: 5h 21m

What companies run services between Mechanicsburg, Cumberland County, PA, USA and Detroit, MI, USA?

Jefferson Lines operates a bus from Harrisburg Bus Station to Detroit Bus Station once daily. Tickets cost $110–160 and the journey takes 12h 50m. Greyhound USA also services this route once daily.

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Bus operators

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Need to know: Greyhound

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