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How to get fromMechanicsburg to Great Smoky Mountainsby plane, car, bus, or train

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There are 8 ways to get from Mechanicsburg to Great Smoky Mountains by plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Harrisburg International Airport, drive

    best
    1. Fly from Harrisburg International Airport (MDT) to Mcghee Tyson Airport (TYS)plane plane MDT - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    8h 6m
    $132–720

  2. Drive 552.4 mi

    cheapest
    1. Drive from Mechanicsburg to Great Smoky Mountainscar car 552.4 mi
    9h 50m
    $101–146

  3. Bus, train, drive

    1. Take the bus from Harrisburg Bus Station to Washington Union Stationbus bus
    2. Take the train from Washington Union Station to Greensborotrain train
    3. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    18h 1m
    $141–297

  4. Train, bus, drive via Greensboro

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Greensborotrain train
    3. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    19h 19m
    $189–422

  5. Train to Philadelphia International Airport, fly, drive

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Mcghee Tyson Airport (TYS)plane plane PHL - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    8h 45m
    $204–1,041

  6. Train, bus, drive

    1. Take the train from Harrisburg to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    3. Drive from Knoxville, TN to Great Smoky Mountainscar car
    20h 26m
    $166–263

  7. Bus, drive

    1. Take the bus from Harrisburg Bus Station to New York City Chinatownbus bus
    2. Take the bus from New York to Knoxvillebus bus Nyc
    3. Drive from Knoxville to Great Smoky Mountainscar car
    21h 13m
    $139–217

  8. Bus, drive via Farragut

    1. Take the bus from Harrisburg Bus Station to New York City Chinatownbus bus
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    3. Drive from Knoxville, TN to Great Smoky Mountainscar car
    21h 17m
    $138–185

Harrisburg International Airport (MDT) to Mcghee Tyson Airport (TYS) flights

Calendar99Weekly Planes
Duration5h 5mAverage Duration
Ticket$120Cheapest Price
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Questions & Answers

Map of how to get from Mechanicsburg to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 574.3 mi
  • Duration: 8h 6m

What companies run services between Mechanicsburg, Cumberland County, PA, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Mechanicsburg to Great Smoky Mountains. However, you can take the bus to Market Square Transfer Center, take the line 7 bus to Harrisburg International Airport, walk to Harrisburg International Airport (MDT) airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a bus from E Main St & Arch St EB to Great Smoky Mountains via Market Square Transfer Center, Harrisburg Bus Station, Washington Union Station, Washington Union Station, Greensboro, Greensboro Bus Stop, and Asheville, NC in around 18h 1m.

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