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How to get fromMechanicsburg to Niagara Fallsby bus (Greyhound), train (Amtrak), car, train, plane, or bus

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There are 5 ways to get from Mechanicsburg to Niagara Falls by bus (Greyhound), train (Amtrak), car, train, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Harrisburg, Pa to Scranton, Pabus bus 770
    2. Take the bus from Scranton Bus Station to Buffalobus bus Greyhound US0205 / ...
    12h 50m
    $67–159

  2. Drive 308.6 mi

    cheapest
    1. Drive from Mechanicsburg to Niagara Fallscar car 308.6 mi
    6h 9m
    $57–82

  3. Train (Amtrak)

    1. Take the train from Harrisburg to Ny Moynihan Train Hall At Penn Stationtrain train Keystone Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Niagara Falls Amtrak Stationtrain train Empire Service / ...
    15h 8m
    $211–442

  4. Train, fly, bus

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Buffalo Niagara International Airport (BUF)plane plane PHL - BUF
    3. Take the bus from Buffalo Niagara International Airport to Niagara Falls USAbus bus
    8h 14m
    $134–734

  5. Bus via Sandy

    1. Take the bus from Harrisburg, Pa to Dubois, Pabus bus 731
    2. Take the bus from DuBois to Buffalobus bus Fab510
    13h 20m
    $60–204

Mechanicsburg to Niagara Falls by bus and foot

Calendar7Weekly Services
Duration12h 50mAverage Duration
Ticket$67Cheapest Price
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Questions & Answers

Map of how to get from Mechanicsburg to Niagara Falls.ExpandLaunch map view
  • Distance: 427.8 mi
  • Duration: 12h 50m

What companies run services between Mechanicsburg, Cumberland County, PA, USA and Niagara Falls, NY, USA?

You can take a bus from E Main St & Arch St EB to Main Street & Pine Avenue via Market Square Transfer Center, Harrisburg, Pa, Scranton Bus Station, Buffalo, and Ellicott Street & MTC Static in around 12h 50m. Alternatively, you can take a bus from E Main St & Race St EB to Niagara Falls Amtrak Station via Market Square Transfer Center, Harrisburg, and Ny Moynihan Train Hall At Penn Station in around 15h 8m.

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