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How to get fromMechanicsburg to Roanokeby bus, train, bus (Greyhound), car, plane, or train (Amtrak)

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There are 8 ways to get from Mechanicsburg to Roanoke by bus, train, bus (Greyhound), car, plane, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train

    best
    1. Take the bus from Harrisburg Bus Station to Washington Union Stationbus bus Greyhound US0430
    2. Take the train from Washington Union Station to Roanoketrain train Northeast Regional
    10h 57m
    $88–187

  2. Drive 278.9 mi

    cheapest
    1. Drive from Mechanicsburg to Roanokecar car 278.9 mi
    4h 50m
    $51–74

  3. Bus (Greyhound)

    1. Take the bus from Harrisburg Bus Station to Baltimore Downtown Bus Stationbus bus Greyhound US0430
    2. Take the bus from Baltimore Downtown Bus Station to Roanoke Bus Stopbus bus Greyhound US0600
    11h 41m
    $52–105

  4. Fly Harrisburg International Airport to Roanoke Regional Airport-Woodrum Field

    1. Fly from Harrisburg International Airport (MDT) to Roanoke Regional Airport-Woodrum Field (ROA)plane plane MDT - ROA
    6h 55m
    $101–659

  5. Train (Amtrak)

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Washington Union Stationtrain train
    3. Take the train from Washington Union Station to Roanoketrain train
    11h 39m
    $131–872

  6. Bus via Washington

    1. Take the bus from Harrisburg Bus Station to Washington Union Stationbus bus Greyhound US0430
    2. Take the bus from Washington Union Station to Salem VDOT Park & Ridebus bus Highlands Rhythm
    12h 5m
    $54–91

  7. Train to Philadelphia International Airport, fly to Roanoke Regional Airport-Woodrum Field

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Roanoke Regional Airport-Woodrum Field (ROA)plane plane PHL - ROA
    7h 26m
    $103–510

  8. Fly Harrisburg International Airport to Lynchburg Regional Airport, train

    1. Fly from Harrisburg International Airport (MDT) to Lynchburg Regional Airport (LYH)plane plane MDT - LYH
    2. Take the train from Lynchburg to Roanoketrain train
    9h 51m
    $110–691

Mechanicsburg to Roanoke by bus, foot, and train

Calendar7Weekly Services
Duration10h 57mAverage Duration
Ticket$88Cheapest Price
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Questions & Answers

Map of how to get from Mechanicsburg to Roanoke.ExpandLaunch map view
  • Distance: 346.8 mi
  • Duration: 10h 57m

What companies run services between Mechanicsburg, Cumberland County, PA, USA and Roanoke, VA, USA?

You can take a bus from E Main St & Arch St EB to Roanoke Bus Stop via Market Square Transfer Center, Harrisburg Bus Station, and Baltimore Downtown Bus Station in around 11h 41m. Alternatively, United Airlines, American Airlines, and Delta fly from Harrisburg International Airport (MDT) to Roanoke Regional Airport-Woodrum Field (ROA) hourly.

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