There are 5 ways to get from Mechanicsburg to St. Louis by plane, bus (Greyhound), train (Amtrak), car, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Harrisburg International Airport
best- Fly from Harrisburg International Airport (MDT) to Lambert–St. Louis International Airport (STL)plane MDT - STL
7h 22m$245–1,207Bus
cheapest- Take the bus from Harrisburg Bus Station to St Louis Bus Stationbus Greyhound US0421
19h 36m$121–252Train (Amtrak)
- Take the train from Harrisburg to Pittsburgh Amtrak Stationtrain
- Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain
- Take the train from Chicago Union Station to St. Louistrain
23h 32m$321–672Drive 772 mi
- Drive from Mechanicsburg to St. Louiscar 772 mi
13h 16m$141–204Train to Philadelphia International Airport, fly
- Take the train from Harrisburg to 30th Street Stationtrain
- Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)plane PHL - STL
7h 51m$197–1,178
Mechanicsburg to St. Louis by bus and foot
Questions & Answers
The cheapest way to get from Mechanicsburg to St. Louis is to bus which costs $120 - $260 and takes 19h 36m.
The fastest way to get from Mechanicsburg to St. Louis is to fly which takes 7h 22m and costs $240 - $1,300.
No, there is no direct bus from Mechanicsburg to St. Louis station. However, there are services departing from E Main St & Race St EB and arriving at St Louis Bus Station via Harrisburg Bus Station. The journey, including transfers, takes approximately 19h 36m.
No, there is no direct train from Mechanicsburg to St. Louis. However, there are services departing from Harrisburg and arriving at St. Louis via Pittsburgh Amtrak Station and Chicago Union Station. The journey, including transfers, takes approximately 23h 32m.
The distance between Mechanicsburg and St. Louis is 769 miles. The road distance is 776.5 miles.
The best way to get from Mechanicsburg to St. Louis without a car is to bus which takes 19h 36m and costs $120 - $260.
It takes approximately 7h 22m to get from Mechanicsburg to St. Louis, including transfers.
Mechanicsburg to St. Louis bus services, operated by Greyhound-us, depart from Harrisburg Bus Station.
Mechanicsburg to St. Louis train services, operated by Amtrak, depart from Harrisburg station.
The best way to get from Mechanicsburg to St. Louis is to fly which takes 7h 22m and costs $240 - $1,300. Alternatively, you can bus, which costs $120 - $260 and takes 19h 36m, you could also train, which costs $320 - $700 and takes 23h 32m.
What companies run services between Mechanicsburg, Cumberland County, PA, USA and St. Louis, MO, USA?
Delta, United Airlines, and American Airlines fly from Harrisburg International Airport (MDT) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, Greyhound-us operates a bus from Harrisburg Bus Station to St Louis Bus Station twice daily, and the journey takes 18h 5m. Greyhound USA also services this route twice daily.
- Website
- aa.com
Flights from Harrisburg International Airport to Lambert–St. Louis International Airport via Charlotte
- Ave. Duration
- 5h 11m
- When
- Every day
- Estimated price
- $280–1,400
Flights from Harrisburg International Airport to Lambert–St. Louis International Airport via Philadelphia International Airport
- Ave. Duration
- 5h 29m
- When
- Every day
- Estimated price
- $270–1,300
Flights from Harrisburg International Airport to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 6h 37m
- When
- Every day
- Estimated price
- $260–1,300
Flights from Philadelphia International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 2h 32m
- When
- Every day
- Estimated price
- $170–850
- Website
- delta.com
Flights from Harrisburg International Airport to Lambert–St. Louis International Airport via Detroit
- Ave. Duration
- 4h 52m
- When
- Every day
- Estimated price
- $250–1,300
Flights from Harrisburg International Airport to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 6h 1m
- When
- Every day
- Estimated price
- $310–1,400
Flights from Philadelphia International Airport to Lambert–St. Louis International Airport via Detroit
- Ave. Duration
- 4h 29m
- When
- Every day
- Estimated price
- $180–900
- Website
- southwest.com
Flights from Philadelphia International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 2h 20m
- When
- Every day
- Estimated price
- $170–850
Flights from Philadelphia International Airport to Lambert–St. Louis International Airport via Chicago Midway
- Ave. Duration
- 4h 20m
- When
- Tuesday and Wednesday
- Estimated price
- $190–900
Flights from Philadelphia International Airport to Lambert–St. Louis International Airport via Nashville
- Ave. Duration
- 4h 20m
- When
- Sunday
- Estimated price
- $190–950
- Website
- united.com
Flights from Harrisburg International Airport to Lambert–St. Louis International Airport via Washington Dulles
- Ave. Duration
- 4h 51m
- When
- Every day
- Estimated price
- $240–1,200
Flights from Harrisburg International Airport to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 4h 56m
- When
- Every day
- Estimated price
- $260–1,300
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Harrisburg to Pittsburgh Amtrak Station
- Ave. Duration
- 5h 29m
- Frequency
- Once daily
- Estimated price
- $80–160
- Website
- https://www.amtrak.com/home.html
Train from Pittsburgh Amtrak Station to Chicago Union Station
- Ave. Duration
- 9h 46m
- Frequency
- Once daily
- Estimated price
- $150–320
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to St. Louis
- Ave. Duration
- 4h 46m
- Frequency
- 5 times a day
- Estimated price
- $90–190
- Website
- https://www.amtrak.com/home.html
Train from Harrisburg to 30th Street Station
- Ave. Duration
- 1h 44m
- Frequency
- Every 2 hours
- Estimated price
- $30–70
- Website
- https://www.amtrak.com/home.html
#mediaviewer/File:Amtrak_%22Pennsylvanian%22_at_Bryn_Mawr,_PA.jpg "Pennsylvanian exterior")
- Website
- greyhound.com
Bus from Harrisburg Bus Station to St Louis Bus Station
- Ave. Duration
- 18h 5m
- Frequency
- Twice daily
- Schedules at
- greyhound.com
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Harrisburg Bus Station to St Louis Bus Station
- Ave. Duration
- 18h 5m
- Frequency
- Twice daily
- Estimated price
- $120–250
- Website
- https://www.greyhound.com/
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
More Questions & Answers
Mechanicsburg to St. Louis bus services, operated by Greyhound-us, arrive at St Louis Bus Station.
St. Louis is 1h behind Mechanicsburg. It is currently 9:29 PM in Mechanicsburg and 8:29 PM in St. Louis.
Mechanicsburg to St. Louis train services, operated by Amtrak, arrive at Pittsburgh Amtrak Station.
Yes, the driving distance between Mechanicsburg to St. Louis is 776 miles. It takes approximately 13h 16m to drive from Mechanicsburg to St. Louis.
There are 485+ hotels available in St. Louis.