Rome2Rio

How to get fromMechanicsburg to St. Louisby plane, bus (Greyhound), train (Amtrak), car, or train

Find Transport to St. Louis

See all options

There are 5 ways to get from Mechanicsburg to St. Louis by plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Harrisburg International Airport

    best
    1. Fly from Harrisburg International Airport (MDT) to Lambert–St. Louis International Airport (STL)plane plane MDT - STL
    7h 29m
    $105–607

  2. Bus (Greyhound)

    1. Take the bus from Harrisburg Bus Station to St Louis Bus Stationbus bus Greyhound US0421
    20h 1m
    $141–222

  3. Train (Amtrak)

    1. Take the train from Harrisburg to Pittsburgh Amtrak Stationtrain train
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    23h 32m
    $541–862

  4. Drive  772 mi

    1. Drive from Mechanicsburg to St. Louiscar car 772 mi
    13h 15m
    $141–204

  5. Train to Philadelphia International Airport, fly

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)plane plane PHL - STL
    8h 2m
    $181–849

Mechanicsburg to St. Louis by bus and foot (Greyhound)

Calendar14Weekly Services
Duration20h 1mAverage Duration
Ticket$141Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Mechanicsburg to St. Louis.ExpandLaunch map view
  • Distance: 764.2 mi
  • Duration: 7h 29m

What companies run services between Mechanicsburg, Cumberland County, PA, USA and St. Louis, MO, USA?

Delta, American Airlines, and United Airlines fly from Harrisburg International Airport (MDT) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, Greyhound USA operates a bus from Harrisburg Bus Station to St Louis Bus Station twice daily. Tickets cost $140–220 and the journey takes 18h 30m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There