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How to get fromMedellín to Santa Cruzby plane, taxi, bus, car, or train

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There are 9 ways to get from Medellín to Santa Cruz by plane, taxi, bus, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Enrique Olaya Herrera Airport

    best
    1. Fly from Enrique Olaya Herrera Airport (EOH) to Viru Viru International Airport (VVI)plane plane EOH - VVI
    10h 55m
    $588–2,073

  2. Drive 5,133.4 km

    cheapest
    1. Drive from Medellín to Santa Cruz de la Sierracar car 5,133.4 km
    3d 4h
    $268–388

  3. Taxi, bus via Iquique

    1. Take the taxi from Medellín to Rumichacataxi taxi
    2. Take the bus from Rumichaca to Gran Terminal Terrestre Plaza Nortebus bus
    3. Take the bus from Gran Terminal Terrestre Plaza Norte to Tacnabus bus
    4. Take the bus from Terminal Terrestre Internacional Manuel A. Odría to Terminal Internacional Aricabus bus
    5. Take the bus from Terminal Rodoviario de Arica to Rodovario de Iquiquebus bus
    6. Take the bus from Iquique to Santa Cruzbus bus
    3d 21h

  4. Fly from Medellin Jose Marie Cordova

    1. Fly from Medellin Jose Marie Cordova (MDE) to Viru Viru International Airport (VVI)plane plane MDE - VVI
    9h 5m
    $420–856

  5. Bus to Manizales, fly

    1. Take the bus from Terminal del Norte to Terminal de Transportes de Manizalesbus bus
    2. Fly from Manizales (MZL) to Viru Viru International Airport (VVI)plane plane MZL - VVI
    15h 21m
    $500–1,828

  6. Taxi to Pereira, fly

    1. Take the taxi from Medellín to Pereirataxi taxi
    2. Fly from Pereira (PEI) to Viru Viru International Airport (VVI)plane plane PEI - VVI
    14h 36m
    $414–1,014

  7. Taxi, bus

    1. Take the taxi from Medellín to Rumichacataxi taxi
    2. Take the bus from Rumichaca to Gran Terminal Terrestre Plaza Nortebus bus
    3. Take the bus from Oltursa Lima Terminal to La Pazbus bus
    4. Take the bus from La Paz to Santa Cruzbus bus
    3d 23h
    $1,050–1,151

  8. Taxi, bus #2

    1. Take the taxi from Medellín to Rumichacataxi taxi
    2. Take the bus from Rumichaca to Terminal Terrestre Quitumbebus bus
    3. Take the bus from Terminal Terrestre Quitumbe to Lima Javier Pradobus bus
    4. Take the bus from Lima - Terminal Arriola to La Pazbus bus
    5. Take the bus from La Paz to Santa Cruzbus bus
    4d 10h
    $973–1,538

  9. Taxi, bus, train

    1. Take the taxi from Medellín to Rumichacataxi taxi
    2. Take the bus from Rumichaca to Gran Terminal Terrestre Plaza Nortebus bus
    3. Take the bus from Gran Terminal Terrestre Plaza Norte to Terminal de Omnibus de Jujuybus bus
    4. Take the bus from Terminal de Omnibus de Jujuy to Terminal Pichanalbus bus
    5. Take the bus from Pichanal to Salvador Mazzabus bus
    6. Take the train from Yacuiba to Santa Cruztrain train
    5d
    $1,034–1,190

Enrique Olaya Herrera Airport (EOH) to Viru Viru International Airport (VVI) flights

Calendar41Weekly Planes
Duration10h 8mAverage Duration
Ticket$587Cheapest Price
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Questions & Answers

Map of how to get from Medellín to Santa Cruz.ExpandLaunch map view
  • Distance: 3,009.3 km
  • Duration: 10h 55m

What companies run services between Medellín, Colombia and Santa Cruz, Bolivia?

Easyfly, Avianca - Aerovías del Continente Americano S.A., and Euroairlines fly from Enrique Olaya Herrera Airport (EOH) to Viru Viru International Airport (VVI) every 4 hours.

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