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How to get fromMedellín to Santiagoby plane, taxi, bus, or car

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There are 7 ways to get from Medellín to Santiago by plane, taxi, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Medellin Jose Marie Cordova

    best
    1. Fly from Medellin Jose Marie Cordova (MDE) to Comodoro Arturo Merino Benítez International Airport (SCL)plane plane MDE - SCL
    9h 14m
    $228–502

  2. Taxi, bus via Tumbes

    1. Take the taxi from Medellín to Rumichacataxi taxi
    2. Take the bus from Tulcán to Huaquillasbus bus
    3. Take the bus from Tumbes to Gran Terminal Terrestre Plaza Nortebus bus
    4. Take the bus from Gran Terminal Terrestre Plaza Norte to Terminal Sur de Santiagobus bus
    4d 10h
    $877–995

  3. Drive  6,134.3 km

    1. Drive from Medellín to Santiagocar car 6,134.3 km
    3d 13h
    $856–1,237

  4. Fly from Enrique Olaya Herrera Airport

    1. Fly from Enrique Olaya Herrera Airport (EOH) to Comodoro Arturo Merino Benítez International Airport (SCL)plane plane EOH - SCL
    10h 10m
    $749–2,387

  5. Bus to Manizales, fly

    1. Take the bus from Terminal del Norte to Terminal de Transportes de Manizalesbus bus
    2. Fly from Manizales (MZL) to Comodoro Arturo Merino Benítez International Airport (SCL)plane plane MZL - SCL
    15h 18m
    $429–1,329

  6. Taxi to Pereira, fly

    1. Take the taxi from Medellín to Pereirataxi taxi
    2. Fly from Pereira (PEI) to Comodoro Arturo Merino Benítez International Airport (SCL)plane plane PEI - SCL
    15h 32m
    $493–755

  7. Taxi, bus

    1. Take the taxi from Medellín to Rumichacataxi taxi
    2. Take the bus from Tulcán to Terminal Terrestre Quitumbebus bus
    3. Take the bus from Terminal Terrestre Quitumbe to Lima Javier Pradobus bus
    4. Take the bus from Lima Javier Prado to Terminal Sur de Santiagobus bus
    4d 17h
    $895–1,020

Medellin Jose Marie Cordova (MDE) to Comodoro Arturo Merino Benítez International Airport (SCL) flights

Calendar61Weekly Planes
Duration8h 36mAverage Duration
Ticket$198Cheapest Price
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Comparing Your Travel Options

Map of how to get from Medellín to Santiago.ExpandLaunch map view
  • Distance: 4,461.1 km
  • Duration: 9h 14m

What companies run services between Medellín, Colombia and Santiago, Chile?

JetSMART, Avianca - Aerovías del Continente Americano S.A., and LATAM Chile fly from Medellin Jose Marie Cordova (MDE) to Comodoro Arturo Merino Benítez International Airport (SCL) every 3 hours.

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Rome2Rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including Need to know: Eurostar, Train travel in France: A guide to SNCF, and Italian Lakes: Getting around by train - to help you get the most out of your next trip.