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How to get fromMedford to Buffaloby tram, plane, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus)

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There are 6 ways to get from Medford to Buffalo by tram, plane, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Tram, fly to Buffalo Niagara International Airport

    best
    1. Take the tram from Medford/Tufts to Government Centertram tram
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    4h 22m
    $87–534

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Boston to Buffalobus bus Greyhound US0171
    11h 36m
    $72–144

  3. Train (Amtrak)

    1. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    14h 9m
    $154–472

  4. Drive 454.2 mi

    1. Drive from Medford to Buffalocar car 454.2 mi
    7h 59m
    $83–120

  5. Fly to Rochester, bus

    1. Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane plane BOS - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    6h 2m
    $119–599

  6. Bus via Ithaca

    1. Take the bus from Boston to Ithacabus bus FlixBus 2691
    2. Take the bus from Ithaca to Buffalobus bus FlixBus N2687 / ...
    13h 42m
    $90–212

Medford to Buffalo by bus and foot (Greyhound)

Calendar7Weekly Services
Duration11h 36mAverage Duration
Ticket$72Cheapest Price
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Questions & Answers

Map of how to get from Medford to Buffalo.ExpandLaunch map view
  • Distance: 415.9 mi
  • Duration: 4h 22m

What companies run services between Medford, MA, USA and Buffalo, NY, USA?

Greyhound USA operates a bus from Boston to Buffalo once daily. Tickets cost $70–140 and the journey takes 10h 5m. Alternatively, Amtrak operates a train from Boston to Buffalo Depew Station once daily. Tickets cost $150–330 and the journey takes 11h 32m.

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