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How to get fromMedford to Knoxvilleby plane, bus, train, or car

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There are 7 ways to get from Medford to Knoxville by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Rogue Valley International - Medford Airport (MFR) to Mcghee Tyson Airport (TYS)plane plane MFR - TYS
    6h 41m
    $294–1,037

  2. Fly to Asheville Regional Airport, drive

    cheapest
    1. Fly from Rogue Valley International - Medford Airport (MFR) to Asheville Regional Airport (AVL)plane plane MFR - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    8h 43m
    $148–544

  3. Bus, train

    1. Take the bus from Medford to JCT Transit Hub - 300 NW 5th St - Rt 100bus bus
    2. Take the bus from Grants Pass to Portland Curbside Bus Stopbus bus
    3. Take the train from Portland to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus
    3d 16h
    $1,164–2,390

  4. Bus, train via Los Angeles

    1. Take the bus from Front Street Station - Medford to Klamath Falls Amtrak Stationbus bus
    2. Take the train from Klamath Falls to Los Angelestrain train
    3. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    5. Take the bus from New York to Knoxvillebus bus
    4d 11h
    $899–1,746

  5. Drive 2,506.5 mi

    1. Drive from Medford to Knoxvillecar car 2,506.5 mi
    42h 36m
    $458–661

  6. Fly to Nashville, drive

    1. Fly from Rogue Valley International - Medford Airport (MFR) to Nashville (BNA)plane plane MFR - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    8h 59m
    $157–574

  7. Bus, train via Klamath Falls

    1. Take the bus from Front Street Station - Medford to Klamath Falls Amtrak Stationbus bus
    2. Take the train from Klamath Falls to Portlandtrain train
    3. Take the train from Portland to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    5. Take the bus from New York to Knoxvillebus bus
    3d 21h
    $1,284–2,656

Rogue Valley International - Medford Airport (MFR) to Mcghee Tyson Airport (TYS) flights

Calendar19Weekly Planes
Duration7h 51mAverage Duration
Ticket$238Cheapest Price
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Questions & Answers

Map of how to get from Medford to Knoxville.ExpandLaunch map view
  • Distance: 2,127.5 mi
  • Duration: 6h 41m

What companies run services between Medford, OR, USA and Knoxville, TN, USA?

United Airlines, Allegiant Air, and Southwest Airlines fly from Rogue Valley International - Medford Airport (MFR) to Mcghee Tyson Airport (TYS) 3 times a day.

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