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How to get fromMedford to Louisvilleby plane, bus, train, bus (Greyhound), or car

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There are 8 ways to get from Medford to Louisville by plane, bus, train, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Louisville International Airport

    best
    1. Fly from Rogue Valley International - Medford Airport (MFR) to Louisville International Airport (SDF)plane plane MFR - SDF
    7h 37m
    $172–680

  2. Bus, train

    1. Take the bus from Front Street Station - Medford to Newman United Methodist Church - Grants Passbus bus
    2. Take the bus from Grants Pass to Portland Curbside Bus Stopbus bus
    3. Take the train from Portland to Chicago Union Stationtrain train
    4. Take the bus from Chicago Union Station to Louisville, KYbus bus
    2d 14h
    $793–1,677

  3. Bus

    1. Take the bus from Medford to JCT Transit Hub - 300 NW 5th St - Rt 100bus bus 100
    2. Take the bus from Grants Pass to Seattle Bus Stationbus bus
    3. Take the bus from Seattle Bus Station to Denver Union Stationbus bus
    4. Take the bus from Denver Union Station to St Louis Bus Stationbus bus
    5. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    6. Take the bus from Evansville, IN to Louisville, KYbus bus
    2d 17h
    $451–877

  4. Drive 2,295.3 mi

    1. Drive from Medford to Louisvillecar car 2,295.3 mi
    38h 28m
    $419–606

  5. Fly to Blue Grass Airport, drive

    1. Fly from Rogue Valley International - Medford Airport (MFR) to Blue Grass Airport (LEX)plane plane MFR - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    7h 52m
    $267–1,020

  6. Fly to Covington, bus

    1. Fly from Rogue Valley International - Medford Airport (MFR) to Covington (CVG)plane plane MFR - CVG
    2. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    9h 58m
    $194–769

  7. Fly to Indianapolis, bus

    1. Fly from Rogue Valley International - Medford Airport (MFR) to Indianapolis (IND)plane plane MFR - IND
    2. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    10h 52m
    $198–727

  8. Bus, train via Indianapolis

    1. Take the bus from Medford Airport to Klamath Fallsbus bus
    2. Take the train from Klamath Falls to Portlandtrain train
    3. Take the train from Portland to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to Indianapolistrain train
    5. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    2d 18h
    $893–1,927

Medford to Louisville by bus and train

Calendar7Weekly Services
Duration2d 14hAverage Duration
Ticket$793Cheapest Price
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Questions & Answers

Map of how to get from Medford to Louisville.ExpandLaunch map view
  • Distance: 1,968.8 mi
  • Duration: 7h 37m

What companies run services between Medford, OR, USA and Louisville, KY, USA?

United Airlines, American Airlines, and Southwest Airlines fly from Rogue Valley International - Medford Airport (MFR) to Louisville International Airport (SDF) 3 times a day. Alternatively, you can take a bus from Medford to Louisville, KY via JCT Transit Hub - 300 NW 5th St - Rt 100, Grants Pass, Seattle Bus Station, Denver Union Station, St Louis Bus Station, and Evansville, IN in around 2d 17h.

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