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How to get fromMedford to Santa Anaby plane, bus (Greyhound), bus, train, or car

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There are 4 ways to get from Medford to Santa Ana by plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Rogue Valley International - Medford Airport (MFR) to John Wayne Airport Orange County (SNA)plane plane MFR - SNA
    2h 8m
    $266–403

  2. Bus

    cheapest
    1. Take the bus from Medford to JCT Transit Hub - 300 NW 5th St - Rt 100bus bus 100
    2. Take the bus from Grants Pass to Sacramento Bus Stationbus bus
    3. Take the bus from Sacramento Bus Station to Santa Ana Bus Stopbus bus
    23h
    $116–227

  3. Bus, train

    1. Take the bus from Medford Airport to Klamath Fallsbus bus
    2. Take the train from Klamath Falls to Los Angelestrain train
    3. Take the train from Los Angeles to Santa Anatrain train
    27h 28m
    $292–665

  4. Drive 722.2 mi

    1. Drive from Medford to Santa Anacar car 722.2 mi
    11h 58m
    $132–191

Medford to Santa Ana by bus and foot

Calendar7Weekly Services
Duration23hAverage Duration
Ticket$116Cheapest Price
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Questions & Answers

Map of how to get from Medford to Santa Ana.ExpandLaunch map view
  • Distance: 665 mi
  • Duration: 2h 8m

What companies run services between Medford, OR, USA and Santa Ana, CA, USA?

Allegiant Air, Alaska Airlines, Inc., and two other airlines fly from Rogue Valley International - Medford Airport (MFR) to John Wayne Airport Orange County (SNA) 4 times a day. Alternatively, you can take a bus from Medford to Santa Ana Bus Stop via JCT Transit Hub - 300 NW 5th St - Rt 100, Grants Pass, and Sacramento Bus Station in around 23h.

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Need to know: Greyhound

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