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How to get fromMedford to Santa Rosaby plane, bus (Amtrak), bus, train, or car

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There are 6 ways to get from Medford to Santa Rosa by plane, bus (Amtrak), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Sonoma County Airport

    best
    1. Fly from Rogue Valley International - Medford Airport (MFR) to Sonoma County Airport (STS)plane plane MFR - STS
    4h 27m
    $534–629

  2. Drive 339.4 mi

    cheapest
    1. Drive from Medford to Santa Rosacar car 339.4 mi
    6h 16m
    $62–90

  3. Bus

    1. Take the bus from Front Street Station - Medford to Crescent City Cultural Center/CoCbus bus
    2. Take the bus from Grocery Outlet to Arcata Transit Centerbus bus 20
    3. Take the bus from Arcata to Santa Rosa Amtrak Bus Stopbus bus
    14h 1m
    $102–169

  4. Bus, train

    1. Take the bus from Front Street Station - Medford to Klamath Falls Amtrak Stationbus bus
    2. Take the train from Klamath Falls to Martineztrain train
    3. Take the bus from Martinez to Santa Rosa Amtrak Bus Stopbus bus
    16h 16m
    $156–322

  5. Fly to San Francisco International Airport, bus, train

    1. Fly from Rogue Valley International - Medford Airport (MFR) to San Francisco International Airport (SFO)plane plane MFR - SFO
    2. Take the bus from San Francisco Airport to Larkspur - dropoffbus bus
    3. Take the train from SMART Larkspur to SMART Santa Rosa Downtowntrain train
    4h 41m
    $153–278

  6. Bus, train via San Rafael

    1. Take the bus from Medford Airport to Klamath Fallsbus bus
    2. Take the train from Klamath Falls to Martineztrain train
    3. Take the train from SMART San Rafael to SMART Santa Rosa Downtowntrain train
    16h 33m
    $145–323

Medford to Santa Rosa by bus

Calendar7Weekly Buses
Duration14h 1mAverage Duration
Ticket$102Cheapest Price
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Questions & Answers

Map of how to get from Medford to Santa Rosa.ExpandLaunch map view
  • Distance: 275.8 mi
  • Duration: 4h 27m

What companies run services between Medford, OR, USA and Santa Rosa, CA, USA?

Alaska Airlines, Inc., Delta, and American Airlines fly from Rogue Valley International - Medford Airport (MFR) to Sonoma County Airport (STS) every 4 hours. Alternatively, you can take a bus from Front Street Station - Medford to Santa Rosa Amtrak Bus Stop via Grocery Outlet and Arcata in around 14h 1m.

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