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How to get fromMedina to Des Moinesby plane, bus (Flixbus, Greyhound), train, bus, car, or bus (Greyhound)

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There are 6 ways to get from Medina to Des Moines by plane, bus (Flixbus, Greyhound), train, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Cleveland-Hopkins International Airport (CLE) to Des Moines (DSM)plane plane CLE - DSM
    4h 17m
    $222–897

  2. Drive 651.4 mi

    cheapest
    1. Drive from Medina to Des Moinescar car 651.4 mi
    11h 5m
    $119–172

  3. Bus

    1. Take the bus from Robert K Pfaff Transit Center - Akron to Chicago Bus Stationbus bus FlixBus N2641
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    17h 14m
    $142–248

  4. Train, bus via Galesburg

    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    3. Take the bus from Galesburg to Des Moinesbus bus
    18h 34m
    $248–480

  5. Train, bus

    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train Floridian / ...
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    17h 14m
    $189–371

  6. Bus via Cleveland

    1. Take the bus from Cleveland to Chicagobus bus Cleveland
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    17h 47m
    $127–229

Cleveland-Hopkins International Airport (CLE) to Des Moines (DSM) flights

Calendar138Weekly Planes
Duration4h 58mAverage Duration
Ticket$144Cheapest Price
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Questions & Answers

Map of how to get from Medina to Des Moines.ExpandLaunch map view
  • Distance: 640.1 mi
  • Duration: 4h 17m

What companies run services between Medina, OH, USA and Des Moines, IA, USA?

Southwest Airlines, Delta, and two other airlines fly from Cleveland-Hopkins International Airport (CLE) to Des Moines (DSM) hourly. Alternatively, you can take a vehicle from Medina to Des Moines via Rothrock Rd @ Montrose, Robert K Pfaff Transit Center - Akron, and Chicago Bus Station in around 17h 14m.

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