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How to get fromMedina to St. Louisby plane, bus (Greyhound), train (Amtrak), or car

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There are 5 ways to get from Medina to St. Louis by plane, bus (Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    2h 43m
    $558–979

  2. Drive 522.8 mi

    cheapest
    1. Drive from Medina to St. Louiscar car 522.8 mi
    8h 53m
    $96–138

  3. Bus

    1. Take the bus from West Salem Bus Station to N Wilson Rd & Ferrell Pl - Columbusbus bus Cleveland
    2. Take the bus from Wilson & Ferrell Shell Station - Columbus to St Louis Bus Stationbus bus Greyhound US0421
    12h
    $130–238

  4. Train (Amtrak)

    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train Floridian / ...
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    14h 49m
    $253–500

  5. Bus via Columbus

    1. Take the bus from West Salem Bus Station to Columbusbus bus Greyhound US0105
    2. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    12h 5m
    $130–238

Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL) flights

Calendar63Weekly Planes
Duration3h 17mAverage Duration
Ticket$111Cheapest Price
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Questions & Answers

Map of how to get from Medina to St. Louis.ExpandLaunch map view
  • Distance: 523.3 mi
  • Duration: 2h 43m

What companies run services between Medina, OH, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and two other airlines fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a vehicle from Medina to St Louis Bus Station via West Salem Bus Station and Wilson & Ferrell Shell Station - Columbus in around 12h.

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