There are 10 ways to get from Melbourne to Florida Keys by car, plane, taxi, bus, shuttle, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive to Orlando Sanford, fly to Key West International Airport
best- Drive from Melbourne to Orlando-Sanford-Airport-SFBcar
- Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane SFB - EYW
5h 46m$125–363Drive 316.5 mi
cheapest- Drive from Melbourne to Florida Keyscar 316.5 mi
6h 2m$58–84Taxi, bus via Fort Pierce South
- Take the taxi from Melbourne to Sebastiantaxi
- Take the bus from Sebastian to Fort Piercebus
- Take the bus from Fort Pierce to Miami Airportbus
- Take the bus from Miami Airport Station to Big Pine Keybus
10h 40m$141–215Shuttle, bus
- Take a shuttle bus from Melbourne, FL - Mobil Gas to Orlando Airport
- Take the bus from Orlando to Fort Lauderdale International Airportbus
- Take a shuttle bus from Fort Lauderdale, FL - International Airport to Summerland Key - Mote Marine Lab
13h 53m$260–332Line 20 bus, shuttle to Orlando, fly to Key West International Airport, bus
- Take the bus from Melbourne Square Mall to West New Haven Ave @ Goodwillbus
- Take a shuttle bus from Melbourne, FL - Mobil Gas to Orlando Airport
- Fly from Orlando (MCO) to Key West International Airport (EYW)plane MCO - EYW
- Take the bus from Whitehead & Eaton to Sugarloaf Key - Lower - Opposite Sugarloaf Lodgebus
7h 44m$204–810Taxi, bus, bus to Miami International Airport, fly to Key West International Airport
- Take the taxi from Melbourne to Sebastiantaxi
- Take the bus from Sebastian to Fort Piercebus
- Take the bus from Fort Pierce to Miami Airportbus
- Fly from Miami International Airport (MIA) to Key West International Airport (EYW)plane MIA - EYW
9h 17m$224–475Shuttle to Orlando, fly to Miami International Airport, shuttle
- Take a shuttle bus from Melbourne, FL - Mobil Gas to Orlando Airport
- Fly from Orlando (MCO) to Miami International Airport (MIA)plane MCO - MIA
- Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FL
10h 18m$758–1,350Shuttle to Orlando, fly to Fort Lauderdale–Hollywood International Airport, shuttle
- Take a shuttle bus from Melbourne, FL - Mobil Gas to Orlando Airport
- Fly from Orlando (MCO) to Fort Lauderdale–Hollywood International Airport (FLL)plane MCO - FLL
- Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
10h 45m$478–870Drive, train, bus
- Drive from Melbourne to Orlandocar
- Take the train from Orlando to Miamitrain
- Take the bus from Miami Airport Station to Big Pine Keybus
11h 26m$75–233Taxi, bus
- Take the taxi from Melbourne to Sebastiantaxi
- Take the bus from Sebastian to Miami Airport Stationbus
- Take the bus from Miami Airport Station to Big Pine Keybus
11h 59m$132–196
Melbourne to Florida Keys by bus, shuttle, and foot
Questions & Answers
The cheapest way to get from Melbourne to Florida Keys is to drive which costs $55 - $85 and takes 6h 2m.
The fastest way to get from Melbourne to Florida Keys is to drive and fly which takes 5h 46m and costs $120 - $370.
The distance between Melbourne and Florida Keys is 389 miles. The road distance is 318.4 miles.
The best way to get from Melbourne to Florida Keys without a car is to taxi and bus via Fort Pierce South which takes 10h 40m and costs $140 - $220.
It takes approximately 5h 46m to get from Melbourne to Florida Keys, including transfers.
Yes, the driving distance between Melbourne to Florida Keys is 318 miles. It takes approximately 6h 2m to drive from Melbourne to Florida Keys.
There are 979+ hotels available in Florida Keys.
What companies run services between Melbourne, FL, USA and Florida Keys, FL, USA?
There is no direct connection from Melbourne to Florida Keys. However, you can drive to Orlando-Sanford-Airport-SFB airport, fly to Key West International Airport (EYW), walk to Key West Airport, take the shuttle to Key West, FL, walk to Whitehead & Eaton, take the bus to Sugarloaf Key - Lower - Opposite Sugarloaf Lodge, then walk to Florida Keys. Alternatively, you can take the taxi to Sebastian, take the bus to Fort Pierce, take the bus to Miami Airport, walk to Miami International Airport, take the vehicle to Miami Airport Station, walk to Miami, Airport Intermodal Station, take the bus to Big Pine Key, walk to Big Pine Key - CVS / MM30, take the bus to Sugarloaf Key - Lower - Sugarloaf Lodge, then walk to Florida Keys.
- Website
- aa.com
Flights from Orlando to Key West International Airport via Miami International Airport
- Ave. Duration
- 3h 10m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $35–230
Flights from Miami International Airport to Key West International Airport
- Ave. Duration
- 1h 4m
- When
- Every day
- Estimated price
- $27–210
Flights from Orlando to Miami International Airport
- Ave. Duration
- 1h 14m
- When
- Every day
- Estimated price
- $35–260
- Website
- southwest.com
Flights from Orlando to Miami International Airport
- Ave. Duration
- 1h 12m
- When
- Every day
- Estimated price
- $35–260
Flights from Orlando to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- $35–260
- Website
- allegiantair.com
Flights from Orlando Sanford to Key West International Airport
- Ave. Duration
- 1h 19m
- When
- Thursday, Sunday, and Monday
- Estimated price
- $35–250
- Website
- jetblue.com
Flights from Orlando to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 1h 9m
- When
- Every day
- Estimated price
- $35–260
- Website
- flybreeze.com
Flights from Orlando to Key West International Airport
- Ave. Duration
- 1h 15m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $70–650
- Phone
- +1 831-539-2901
- [email protected]
- Website
- gobrightline.com
Train from Orlando to Miami
- Ave. Duration
- 3h 34m
- Frequency
- Every 2 hours
- Estimated price
- $40–170
- Book at
- https://www.gobrightline.com
- Smart
- $40–90
- Premium
- $110–170
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Sebastian to Fort Pierce
- Ave. Duration
- 40 min
- Frequency
- Once daily
- Estimated price
- $4–9
- Website
- https://www.greyhound.com/
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 40m
- Frequency
- 3 times a day
- Estimated price
- $19–40
- Website
- https://www.greyhound.com/
Bus from Sebastian to Fort Pierce
- Ave. Duration
- 40 min
- Frequency
- Once daily
- Estimated price
- $4–9
- Website
- https://www.greyhound.com/
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 40m
- Frequency
- 3 times a day
- Estimated price
- $19–40
- Website
- https://www.greyhound.com/
Bus from Sebastian to Miami Airport Station
- Ave. Duration
- 5h 20m
- Frequency
- Once daily
- Estimated price
- $25–50
- Website
- https://www.greyhound.com/
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 40m
- Frequency
- 3 times a day
- Estimated price
- $19–40
- Website
- https://www.greyhound.com/
- Phone
- +1 877 733 0724
- Website
- redcoachusa.com
Bus from Fort Pierce to Miami Airport
- Ave. Duration
- 2h 15m
- Frequency
- 3 times a day
- Estimated price
- $30–60
- Website
- https://www.redcoachusa.com
Bus from Fort Pierce to Miami Airport
- Ave. Duration
- 2h 15m
- Frequency
- 3 times a day
- Estimated price
- $30–60
- Website
- https://www.redcoachusa.com
- Phone
- +1 772-343-0217
- Website
- smartshuttleline.com
Shuttle from Melbourne, FL - Mobil Gas to Orlando Airport
- Ave. Duration
- 56 min
- Frequency
- 4 times a day
- Estimated price
- $55–65
- Schedules at
- smartshuttleline.com
- one passenger
- $55–65
Shuttle from Melbourne, FL - Mobil Gas to Orlando Airport
- Ave. Duration
- 56 min
- Frequency
- 4 times a day
- Estimated price
- $55–65
- Schedules at
- smartshuttleline.com
- one passenger
- $55–65
Shuttle from Melbourne, FL - Mobil Gas to Orlando Airport
- Ave. Duration
- 56 min
- Frequency
- 4 times a day
- Estimated price
- $55–65
- Schedules at
- smartshuttleline.com
- one passenger
- $55–65
Shuttle from Melbourne, FL - Mobil Gas to Orlando Airport
- Ave. Duration
- 56 min
- Frequency
- 4 times a day
- Estimated price
- $55–65
- Schedules at
- smartshuttleline.com
- one passenger
- $55–65
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Orlando to Fort Lauderdale International Airport
- Ave. Duration
- 3h 20m
- Frequency
- Twice daily
- Estimated price
- $30–60
- Schedules at
- flixbus.com
- Phone
- +1 (305) 289-9997
- [email protected]
- Website
- keysshuttle.com
Shuttle from Fort Lauderdale, FL - International Airport to Summerland Key - Mote Marine Lab
- Ave. Duration
- 4h
- Frequency
- 3 times a day
- Estimated price
- $170–200
- Website
- https://www.keysshuttle.com
Shuttle from Miami, FL - International Airport to Big Pine Key, FL
- Ave. Duration
- 3h
- Frequency
- 3 times a day
- Estimated price
- $150–180
- Website
- https://www.keysshuttle.com
Shuttle from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
- Ave. Duration
- 3h 30m
- Frequency
- 3 times a day
- Estimated price
- $170–200
- Website
- https://www.keysshuttle.com
- Phone
- +1 321-633-1878
- Website
- 321transit.com
Bus from Melbourne Square Mall to West New Haven Ave @ Goodwill
- Ave. Duration
- 42 min
- Frequency
- Every 2 hours
- Estimated price
- $2
- Website
- https://321transit.com/
- Phone
- +1 305-809-3700
- Website
- cityofkeywest-fl.gov
Bus from Whitehead & Eaton to Sugarloaf Key - Lower - Opposite Sugarloaf Lodge
- Ave. Duration
- 36 min
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- https://www.cityofkeywest-fl.gov/595/Schedules-and-Route-Maps
- Ave. Duration
- 29 min
- Estimated price
- $85–110
Palm Bay Taxi and Transportation
- Phone
- +1-321-221-1101
Palm Bay Taxi and Transportation
- Phone
- +1-321-221-1101
Palm Bay Taxi and Transportation
- Phone
- +1-321-221-1101
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide










