There are 8 ways to get from Melbourne to Key West by car, plane, taxi, bus, shuttle, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive to Orlando Sanford, fly
best- Drive from Melbourne to Orlando-Sanford-Airport-SFBcar
- Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane SFB - EYW
2h 57m$59–282Taxi, bus via Fort Pierce South
- Take the taxi from Melbourne to Sebastiantaxi
- Take the bus from Sebastian to Fort Piercebus
- Take the bus from Fort Pierce to Miami Airportbus
- Take the bus from Miami Airport Station to Big Pine Keybus
- Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus Lks
11h 26m$141–215Drive 332 mi
- Drive from Melbourne to Key Westcar 332 mi
6h 25m$61–88Line 20 bus, shuttle to Orlando, fly
- Take the bus from Melbourne Square Mall to West New Haven Ave @ Goodwillbus
- Take a shuttle bus from Melbourne, FL - Mobil Gas to Orlando Airport
- Fly from Orlando (MCO) to Key West International Airport (EYW)plane MCO - EYW
4h 58m$132–730Fly from Melbourne International Airport
- Fly from Melbourne International Airport (MLB) to Key West International Airport (EYW)plane MLB - EYW
6h 6m$98–404Taxi, bus, bus to Miami International Airport, fly
- Take the taxi from Melbourne to Sebastiantaxi
- Take the bus from Sebastian to Fort Piercebus
- Take the bus from Fort Pierce to Miami Airportbus
- Fly from Miami International Airport (MIA) to Key West International Airport (EYW)plane MIA - EYW
6h 30m$158–384Drive, train, bus
- Drive from Melbourne to Orlandocar
- Take the train from Orlando to Miamitrain
- Take the bus from Miami Airport Station to Big Pine Keybus
- Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus Lks
12h 12m$75–233Taxi, bus
- Take the taxi from Melbourne to Sebastiantaxi
- Take the bus from Sebastian to Miami Airport Stationbus
- Take the bus from Miami Airport Station to Big Pine Keybus
- Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus Lks
12h 41m$132–196
Orlando Sanford (SFB) to Key West International Airport (EYW) flights
Questions & Answers
The cheapest way to get from Melbourne to Key West is to drive which costs $60 - $90 and takes 6h 25m.
The fastest way to get from Melbourne to Key West is to drive and fly which takes 2h 57m and costs $55 - $290.
The distance between Melbourne and Key West is 370 miles. The road distance is 333.9 miles.
The best way to get from Melbourne to Key West without a car is to taxi and bus via Fort Pierce South which takes 11h 26m and costs $140 - $220.
It takes approximately 2h 57m to get from Melbourne to Key West, including transfers.
Yes, the driving distance between Melbourne to Key West is 334 miles. It takes approximately 6h 25m to drive from Melbourne to Key West.
There are 981+ hotels available in Key West.
What companies run services between Melbourne, FL, USA and Key West, FL, USA?
Delta and American Airlines fly from Melbourne International Airport (MLB) to Key West International Airport (EYW) 4 times a day.
- Website
- aa.com
Flights from Orlando to Key West International Airport via Miami International Airport
- Ave. Duration
- 3h 10m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $35–230
Flights from Melbourne International Airport to Key West International Airport via Charlotte
- Ave. Duration
- 6h 45m
- When
- Every day
- Estimated price
- $90–410
Flights from Miami International Airport to Key West International Airport
- Ave. Duration
- 1h 4m
- When
- Every day
- Estimated price
- $27–200
- Website
- allegiantair.com
Flights from Orlando Sanford to Key West International Airport
- Ave. Duration
- 1h 18m
- When
- Thursday, Sunday, and Monday
- Estimated price
- $35–250
- Website
- delta.com
Flights from Melbourne International Airport to Key West International Airport via Atlanta
- Ave. Duration
- 5h 19m
- When
- Every day
- Estimated price
- $85–390
- Website
- flybreeze.com
Flights from Orlando to Key West International Airport
- Ave. Duration
- 1h 15m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $65–650
- Phone
- +1 831-539-2901
- [email protected]
- Website
- gobrightline.com
Train from Orlando to Miami
- Ave. Duration
- 3h 34m
- Frequency
- Every 2 hours
- Estimated price
- $40–170
- Book at
- https://www.gobrightline.com
- Smart
- $40–90
- Premium
- $110–170
- Website
- greyhound.com
Bus from Sebastian to Fort Pierce
- Ave. Duration
- 40 min
- Frequency
- Once daily
- Schedules at
- greyhound.com
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 35m
- Frequency
- Twice daily
- Schedules at
- greyhound.com
Bus from Sebastian to Fort Pierce
- Ave. Duration
- 40 min
- Frequency
- Once daily
- Schedules at
- greyhound.com
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 35m
- Frequency
- Twice daily
- Schedules at
- greyhound.com
Bus from Sebastian to Miami Airport Station
- Ave. Duration
- 5h 15m
- Frequency
- Once daily
- Schedules at
- greyhound.com
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 35m
- Frequency
- Twice daily
- Schedules at
- greyhound.com
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Sebastian to Fort Pierce
- Ave. Duration
- 40 min
- Frequency
- Once daily
- Estimated price
- $4–9
- Website
- https://www.greyhound.com/
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 40m
- Frequency
- 3 times a day
- Estimated price
- $19–40
- Website
- https://www.greyhound.com/
Bus from Sebastian to Fort Pierce
- Ave. Duration
- 40 min
- Frequency
- Once daily
- Estimated price
- $4–9
- Website
- https://www.greyhound.com/
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 40m
- Frequency
- 3 times a day
- Estimated price
- $19–40
- Website
- https://www.greyhound.com/
Bus from Sebastian to Miami Airport Station
- Ave. Duration
- 5h 20m
- Frequency
- Once daily
- Estimated price
- $25–50
- Website
- https://www.greyhound.com/
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 40m
- Frequency
- 3 times a day
- Estimated price
- $19–40
- Website
- https://www.greyhound.com/
- Phone
- +1 877 733 0724
- Website
- redcoachusa.com
Bus from Fort Pierce to Miami Airport
- Ave. Duration
- 2h 15m
- Frequency
- 3 times a day
- Estimated price
- $30–60
- Website
- https://www.redcoachusa.com
Bus from Fort Pierce to Miami Airport
- Ave. Duration
- 2h 15m
- Frequency
- 3 times a day
- Estimated price
- $30–60
- Website
- https://www.redcoachusa.com
- Phone
- +1 305-809-3700
- Website
- cityofkeywest-fl.gov
Bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Street
- Ave. Duration
- 1h 9m
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- https://www.cityofkeywest-fl.gov/595/Schedules-and-Route-Maps
Bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Street
- Ave. Duration
- 1h 9m
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- https://www.cityofkeywest-fl.gov/595/Schedules-and-Route-Maps
Bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Street
- Ave. Duration
- 1h 9m
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- https://www.cityofkeywest-fl.gov/595/Schedules-and-Route-Maps
- Phone
- +1 321-633-1878
- Website
- 321transit.com
Bus from Melbourne Square Mall to West New Haven Ave @ Goodwill
- Ave. Duration
- 42 min
- Frequency
- Every 2 hours
- Estimated price
- $2
- Website
- https://321transit.com/
- Phone
- +1 772-343-0217
- Website
- smartshuttleline.com
Shuttle from Melbourne, FL - Mobil Gas to Orlando Airport
- Ave. Duration
- 56 min
- Frequency
- 4 times a day
- Estimated price
- $55–65
- Schedules at
- smartshuttleline.com
- one passenger
- $55–65
- Ave. Duration
- 29 min
- Estimated price
- $85–110
Palm Bay Taxi and Transportation
- Phone
- +1-321-221-1101
Palm Bay Taxi and Transportation
- Phone
- +1-321-221-1101
Palm Bay Taxi and Transportation
- Phone
- +1-321-221-1101
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