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How to get fromMelbourne to Knoxvilleby car, plane, train, bus, taxi, or shuttle

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There are 8 ways to get from Melbourne to Knoxville by car, plane, train, bus, taxi, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Orlando Sanford, fly to Mcghee Tyson Airport

    best
    1. Drive from Melbourne to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS)plane plane SFB - TYS
    3h 30m
    $178–739

  2. Drive to Orlando Sanford, fly to Asheville Regional Airport, drive

    cheapest
    1. Drive from Melbourne to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Asheville Regional Airport (AVL)plane plane SFB - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    5h 26m
    $90–394

  3. Drive, train, bus

    1. Drive from Melbourne to Kissimmee Amtrak Stationcar car
    2. Take the train from Kissimmee Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    37h 37m
    $498–927

  4. Taxi, bus

    1. Take the taxi from Melbourne to Sebastiantaxi taxi
    2. Take the bus from Sebastian to Jacksonvillebus bus
    3. Take the bus from Jacksonville to New York City Chinatownbus bus
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    41h 36m
    $365–537

  5. Drive 698.3 mi

    1. Drive from Melbourne to Knoxvillecar car 698.3 mi
    11h 52m
    $128–185

  6. Fly Melbourne International Airport to Mcghee Tyson Airport

    1. Fly from Melbourne International Airport (MLB) to Mcghee Tyson Airport (TYS)plane plane MLB - TYS
    5h 8m
    $176–722

  7. Shuttle to Orlando, fly to Mcghee Tyson Airport

    1. Take a shuttle bus from Melbourne, FL - Mobil Gas to Orlando Airportshuttle bus
    2. Fly from Orlando (MCO) to Mcghee Tyson Airport (TYS)plane plane MCO - TYS
    5h 35m
    $212–736

  8. Shuttle, train, bus

    1. Take a shuttle bus from Melbourne, FL - Mobil Gas to Orlando Airportshuttle bus
    2. Take the train from Kissimmee Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    41h 44m
    $592–1,072

Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS) flights

Calendar11Weekly Planes
Duration1h 38mAverage Duration
Ticket$110Cheapest Price
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Questions & Answers

Map of how to get from Melbourne to Knoxville.ExpandLaunch map view
  • Distance: 596.5 mi
  • Duration: 3h 30m

What companies run services between Melbourne, FL, USA and Knoxville, TN, USA?

Delta and American Airlines fly from Melbourne International Airport (MLB) to Mcghee Tyson Airport (TYS) 4 times a day.

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