Rome2Rio

How to get fromMelbourne to Santeeby plane, car, taxi, bus, train, or shuttle

Find Transport to Santee

See all options

There are 8 ways to get from Melbourne to Santee by plane, car, taxi, bus, train, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Melbourne International Airport to Columbia, drive

    best
    1. Fly from Melbourne International Airport (MLB) to Columbia (CAE)plane plane MLB - CAE
    2. Drive from Columbia-Airport-CAE to Santeecar car
    5h 54m
    $76–388

  2. Taxi, bus via Walterboro, SC

    1. Take the taxi from Melbourne to Sebastiantaxi taxi
    2. Take the bus from Sebastian to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Walterboro, SCbus bus
    4. Take the taxi from Walterboro, SC to Santeetaxi taxi
    10h 30m
    $246–347

  3. Drive, train (Amtrak)

    1. Drive from Melbourne to Kissimmee Amtrak Stationcar car
    2. Take the train from Kissimmee Amtrak Station to Charleston Amtrak Stationtrain train
    3. Drive from Charleston Amtrak Station to Santeecar car
    10h 36m
    $150–310

  4. Drive 413.9 mi

    1. Drive from Melbourne to Santeecar car 413.9 mi
    6h 52m
    $76–110

  5. Fly Melbourne International Airport to Charleston International Airport, drive

    1. Fly from Melbourne International Airport (MLB) to Charleston International Airport (CHS)plane plane MLB - CHS
    2. Drive from Charleston-Airport-CHS to Santeecar car
    6h 11m
    $86–428

  6. Shuttle to Orlando, fly to Charleston International Airport, drive

    1. Take a shuttle bus from Melbourne, FL - Mobil Gas to Orlando Airportshuttle bus
    2. Fly from Orlando (MCO) to Charleston International Airport (CHS)plane plane MCO - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    6h 9m
    $132–342

  7. Taxi, bus

    1. Take the taxi from Melbourne to Sebastiantaxi taxi
    2. Take the bus from Sebastian to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Orangeburgbus bus
    11h 3m
    $231–332

  8. Shuttle, bus

    1. Take a shuttle bus from Melbourne, FL - Mobil Gas to Orlando Airportshuttle bus Northbound
    2. Take the bus from Orlando Bus Station to Orangeburgbus bus FlixBus 2433
    13h 2m
    $200–270

Melbourne International Airport (MLB) to Columbia (CAE) flights

Calendar39Weekly Planes
Duration4h 46mAverage Duration
Ticket$66Cheapest Price
See schedules

Questions & Answers

Map of how to get from Melbourne to Santee.ExpandLaunch map view
  • Distance: 464.2 mi
  • Duration: 5h 54m

What companies run services between Melbourne, FL, USA and Santee, SC, USA?

There is no direct connection from Melbourne to Santee. However, you can take the line 24 bus to Airport Blvd @ Surburban Extended Stay, walk to Melbourne International Airport (MLB) airport, fly to Columbia (CAE), then drive to Santee. Alternatively, you can take the taxi to Sebastian, take the bus to Jacksonville, take the bus to Walterboro, SC, then take the taxi to Santee.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound