There are 6 ways to get from Melipilla to La Serena by bus, plane, car, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, fly
best- Take the bus from Terminal de Buses de Melipilla to Terminal San Borjabus
- Fly from Comodoro Arturo Merino Benítez International Airport (SCL) to La Florida Airport (LSC)plane SCL - LSC
3h 57m$50–112Bus
cheapest- Take the bus from Terminal de Buses de Melipilla to Terminal San Borjabus Melipilla
- Take the bus from Terminal San Borja to Terminal de buses La Serenabus Santiago / ...
7h 27m$10–80Drive 497.5 km
- Drive from Melipilla to La Serenacar 497.5 km
5h 51m$62–89Bus via Santiago
- Take the bus from Terminal de Buses de Melipilla to Terminal San Borjabus Melipilla
- Take the bus from Santiago to Terminal de buses La Serenabus FlixBus CL040 / ...
7h 49m$52–95Bus via Terminal de Buses de Melipilla
- Take the bus from Terminal de Buses de Melipilla to Terminal San Borjabus Melipilla
- Take the bus from Terminal San Borja to Terminal de buses La Serenabus Santiago
8h 20m$19–22Bus via Terminal de Buses de Coquimbo
- Take the bus from Terminal de Buses de Melipilla to Terminal San Borjabus Melipilla
- Take the bus from Terminal San Borja to Terminal de Buses de Coquimbobus Santiago
9h 50m$24–150
Comodoro Arturo Merino Benítez International Airport (SCL) to La Florida Airport (LSC) flights
Questions & Answers
The cheapest way to get from Melipilla to La Serena is to bus via Terminal de Buses de Melipilla which costs $19 - $22 and takes 8h 20m.
The fastest way to get from Melipilla to La Serena is to bus and fly which takes 3h 57m and costs $50 - $120.
No, there is no direct bus from Melipilla to La Serena. However, there are services departing from Terminal de Buses de Melipilla and arriving at Terminal de buses La Serena via Terminal San Borja. The journey, including transfers, takes approximately 7h 27m.
The distance between Melipilla and La Serena is 475 km. The road distance is 497.5 km.
The best way to get from Melipilla to La Serena without a car is to bus which takes 7h 27m and costs $10 - $80.
It takes approximately 3h 57m to get from Melipilla to La Serena, including transfers.
Melipilla to La Serena bus services, operated by Buses Melipilla Santiago, depart from Terminal de Buses de Melipilla station.
Melipilla to La Serena bus services, operated by Buses Melipilla Santiago, arrive at Terminal San Borja station.
Yes, the driving distance between Melipilla to La Serena is 498 km. It takes approximately 5h 51m to drive from Melipilla to La Serena.
Book your Melipilla to La Serena bus tickets online with Omio.
What companies run services between Melipilla, Chile and La Serena, Chile?
You can take a bus from Terminal de Buses de Melipilla to Terminal de buses La Serena via Terminal San Borja in around 7h 27m.
- Website
- latam.com
Flights from Comodoro Arturo Merino Benítez International Airport to La Florida Airport
- Ave. Duration
- 1h 8m
- When
- Every day
- Estimated price
- $40–95
- Website
- skyairline.com
Flights from Comodoro Arturo Merino Benítez International Airport to La Florida Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- $19–75
- Website
- jetsmart.com
Flights from Comodoro Arturo Merino Benítez International Airport to La Florida Airport
- Ave. Duration
- 1h 11m
- When
- Every day
- Estimated price
- $28–75
- Phone
- +56 2 2832 3801
- Website
- chilepasajes.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h
- Frequency
- Every 15 minutes
- Estimated price
- $3
- Book at
- chilepasajes.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h
- Frequency
- Every 15 minutes
- Estimated price
- $3
- Book at
- chilepasajes.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h
- Frequency
- Every 15 minutes
- Estimated price
- $3
- Book at
- chilepasajes.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h
- Frequency
- Every 15 minutes
- Estimated price
- $3
- Book at
- chilepasajes.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h
- Frequency
- Every 15 minutes
- Estimated price
- $3
- Book at
- chilepasajes.cl
- Phone
- +56 9 6190 6054
- [email protected]
- Website
- busesvamos.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h
- Frequency
- Every 20 minutes
- Estimated price
- $2–5
- Book at
- busesvamos.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h
- Frequency
- Every 20 minutes
- Estimated price
- $2–5
- Book at
- busesvamos.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h
- Frequency
- Every 20 minutes
- Estimated price
- $2–5
- Book at
- busesvamos.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h
- Frequency
- Every 20 minutes
- Estimated price
- $2–5
- Book at
- busesvamos.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h
- Frequency
- Every 20 minutes
- Estimated price
- $2–5
- Book at
- busesvamos.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h 7m
- Frequency
- Twice daily
- Estimated price
- $2–4
- Schedules at
- rutabus78.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h 7m
- Frequency
- Twice daily
- Estimated price
- $2–4
- Schedules at
- rutabus78.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h 7m
- Frequency
- Twice daily
- Estimated price
- $2–4
- Schedules at
- rutabus78.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h 7m
- Frequency
- Twice daily
- Estimated price
- $2–4
- Schedules at
- rutabus78.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h 7m
- Frequency
- Twice daily
- Estimated price
- $2–4
- Schedules at
- rutabus78.cl
- Phone
- +56 22 3813 550
- [email protected]
- Website
- plusschile.cl
Bus from Terminal San Borja to Terminal de buses La Serena
- Ave. Duration
- 6h 20m
- Frequency
- Twice daily
- Estimated price
- $14–27
- Book at
- https://www.recorrido.cl/pluss-chile/en
- Semi Cama
- $15–19
- Cama
- $21–27
- Phone
- +56 22 683 8528
- [email protected]
- Website
- flixbus.cl
Bus from Terminal San Borja to Terminal de buses La Serena
- Ave. Duration
- 6h 10m
- Frequency
- Hourly
- Estimated price
- $12–28
- Schedules at
- flixbus.cl
- Semi Cama
- $12–16
- Cama
- $17–28
- Phone
- +56 600 600 0018
- [email protected]
- Website
- pullmanbus.cl
Bus from Terminal San Borja to Terminal de buses La Serena
- Ave. Duration
- 6h 20m
- Frequency
- Hourly
- Estimated price
- $23–40
- Schedules at
- pullmanbus.cl
- Book at
- pullmanbus.cl
- Salón Cama
- $25–40
- Phone
- +56 22 822 7500
- [email protected]
- Website
- turbus.cl
Bus from Terminal San Borja to Terminal de buses La Serena
- Semi Cama
- $17–25
- Cama
- $24–35
- Premium
- $60–75
Bus from Terminal San Borja to Terminal de Buses de Coquimbo
- Semi Cama
- $17–24
- Cama
- $24–35
- Premium
- $60–75
- Phone
- +56 51 221 5300
- [email protected]
- Website
- busesromani.cl
Bus from Terminal San Borja to Terminal de buses La Serena
- Ave. Duration
- 6h 30m
- Frequency
- Hourly
- Estimated price
- $9–26
- Schedules at
- busesromani.cl
- Semi
- $9–11
- Salon
- $22–26
- [email protected]
- Website
- pullmansanandres.cl
Bus from Terminal San Borja to Terminal de buses La Serena
- Ave. Duration
- 6h 30m
- Frequency
- Hourly
- Estimated price
- $35–60
- Schedules at
- pullmansanandres.cl
- Semi Cama
- $35–50
- Cama
- $40–60
Bus from Terminal San Borja to Terminal de buses La Serena
- Ave. Duration
- 7h 5m
- Frequency
- 5 times a day
- Estimated price
- $12–27
- Schedules at
- condorbus.cl
- Semi Cama
- $12–21
- Cama
- $25–27
- Phone
- +56 512 669924
- [email protected]
- Website
- kupos.cl
Bus from Terminal San Borja to Terminal de buses La Serena
- Ave. Duration
- 6h
- Frequency
- Once daily
- Estimated price
- $17–23
- Schedules at
- busesserenamar.cl
- Phone
- +56 57 226 9210
- [email protected]
- Website
- busesramoscholele.cl
Bus from Terminal San Borja to Terminal de buses La Serena
- Ave. Duration
- 4h 30m
- Frequency
- Once daily
- Estimated price
- $14–47
- Schedules at
- busesramoscholele.cl
- Semi cama
- $14–19
- Salón cama
- $44–47
- Phone
- +56 2 3304 8632 / 2 2596 1100
- [email protected]
- Website
- expresonorte.cl
Bus from Terminal San Borja to Terminal de buses La Serena
- Ave. Duration
- 6h 26m
- Frequency
- Once daily
- Estimated price
- $8–25
- Schedules at
- expresonorte.cl
- [email protected]
- Website
- ciktur.cl
Bus from Terminal San Borja to Terminal de buses La Serena
- Ave. Duration
- 6h 50m
- Frequency
- 6 times a week
- Estimated price
- $29–45
- Schedules at
- kupos.cl
- Cama
- $35–45
- Semi Cama
- $29–40
- Website
- https://www.flixbus.cl/
Bus from Santiago to Terminal de buses La Serena
- Ave. Duration
- 6h 10m
- Frequency
- Hourly
- Estimated price
- $50–90
- Schedules at
- flixbus.cl
Bus from Terminal San Borja to Terminal de buses La Serena
- Ave. Duration
- 6h 20m
- Frequency
- Once daily
- Estimated price
- $17
- Schedules at
- paravias.com
Want to know more about travelling around the world?
Rome2Rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including How to plan an amazing trip around Scandinavia, Which London airport should I choose?, and How to get from Gatwick Airport into central London - to help you get the most out of your next trip.
More Questions & Answers
There are 1013+ hotels available in La Serena.






























