There are 6 ways to get from Melipilla to Santa Cruz by bus (Flixbus), bus, train, car, or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus via Litueche
best- Take the bus from Chocalán to Lituechebus FlixBus CL008
- Take the bus from Litueche to Terminal de Buses Santa Cruzbus Litueche
3h 40m$11–16Bus
cheapest- Take the bus from Terminal de Buses de Melipilla to Terminal San Borjabus Melipilla
- Take the bus from Terminal Sur de Santiago to Terminal de Buses Santa Cruzbus Santiago
4h 17m$6–18Bus, train
- Take the bus from Terminal de Buses de Melipilla to Terminal San Borjabus
- Take the train from Estacion Central Alameda to San Fernandotrain
- Take the bus from San Fernando to Santa Cruzbus
5h 10m$12–40Drive 125.8 km
- Drive from Melipilla to Santa Cruzcar 125.8 km
1h 56m$16–23Taxi
- Take the taxi from Melipilla to Santa Cruztaxi 125.8 km
1h 56m$95–120Bus #2
- Take the bus from Terminal de Buses de Melipilla to Terminal San Borjabus Melipilla
- Take the bus from Terminal Sur de Santiago to Santa Cruzbus FlixBus CL027
4h 18m$13–40
Questions & Answers
The cheapest way to get from Melipilla to Santa Cruz is to bus which costs $6 - $18 and takes 4h 17m.
The fastest way to get from Melipilla to Santa Cruz is to drive which takes 1h 56m and costs $15 - $23.
No, there is no direct bus from Melipilla to Santa Cruz. However, there are services departing from Chocalán and arriving at Terminal de Buses Santa Cruz via Litueche. The journey, including transfers, takes approximately 3h 40m.
The distance between Melipilla and Santa Cruz is 157 km. The road distance is 125.8 km.
The best way to get from Melipilla to Santa Cruz without a car is to bus via Litueche which takes 3h 40m and costs $11 - $16.
It takes approximately 3h 40m to get from Melipilla to Santa Cruz, including transfers.
Melipilla to Santa Cruz bus services, operated by Buses Melipilla Santiago, depart from Terminal de Buses de Melipilla station.
Melipilla to Santa Cruz bus services, operated by Buses Melipilla Santiago, arrive at Terminal San Borja station.
Yes, the driving distance between Melipilla to Santa Cruz is 126 km. It takes approximately 1h 56m to drive from Melipilla to Santa Cruz.
Book your Melipilla to Santa Cruz bus tickets online with Omio.
What companies run services between Melipilla, Chile and Santa Cruz, O'Higgins, Chile?
You can take a bus from Chocalán to Terminal de Buses Santa Cruz via Litueche in around 3h 40m.
- Phone
- +56 22 585 5000
- [email protected]
- Website
- efe.cl
Train from Estacion Central Alameda to San Fernando
- Website
- Flixbus Chile
Bus from Chocalán to Litueche
- Ave. Duration
- 1h 10m
- Frequency
- Every 4 hours
- Estimated price
- $7–12
- Schedules at
- Flixbus Chile
Bus from San Fernando to Santa Cruz
- Ave. Duration
- 50 min
- Frequency
- Hourly
- Estimated price
- $4–8
- Schedules at
- Flixbus Chile
Bus from Terminal Sur de Santiago to Santa Cruz
- Ave. Duration
- 2h 40m
- Frequency
- Hourly
- Estimated price
- $19–35
- Schedules at
- Flixbus Chile
- [email protected]
- Website
- Buses Peñablanca
Bus from Litueche to Terminal de Buses Santa Cruz
- Ave. Duration
- 1h 30m
- Frequency
- Every 4 hours
- Estimated price
- $4
- Schedules at
- Buses Peñablanca
- Phone
- +56 2 2832 3801
- Website
- chilepasajes.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h
- Frequency
- Every 15 minutes
- Estimated price
- $3
- Book at
- chilepasajes.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h
- Frequency
- Every 15 minutes
- Estimated price
- $3
- Book at
- chilepasajes.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h
- Frequency
- Every 15 minutes
- Estimated price
- $3
- Book at
- chilepasajes.cl
- Phone
- +56 9 6190 6054
- [email protected]
- Website
- busesvamos.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h
- Frequency
- Every 20 minutes
- Estimated price
- $2–5
- Book at
- busesvamos.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h
- Frequency
- Every 20 minutes
- Estimated price
- $2–5
- Book at
- busesvamos.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h
- Frequency
- Every 20 minutes
- Estimated price
- $2–5
- Book at
- busesvamos.cl
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h 7m
- Frequency
- Twice daily
- Estimated price
- $2–4
- Schedules at
- Ruta Bus 78
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h 7m
- Frequency
- Twice daily
- Estimated price
- $2–4
- Schedules at
- Ruta Bus 78
Bus from Terminal de Buses de Melipilla to Terminal San Borja
- Ave. Duration
- 1h 7m
- Frequency
- Twice daily
- Estimated price
- $2–4
- Schedules at
- Ruta Bus 78
- Phone
- +56 600 600 0018
- [email protected]
- Website
- pullmanbus.cl
Bus from San Fernando to Santa Cruz
- Ave. Duration
- 1h
- Frequency
- 4 times a day
- Estimated price
- $9–30
- Schedules at
- pullmanbus.cl
- Book at
- pullmanbus.cl
- Salón Cama
- $9–30
Bus from Terminal Sur de Santiago to Santa Cruz
- Ave. Duration
- 3h
- Frequency
- 4 times a day
- Estimated price
- $12–35
- Schedules at
- pullmanbus.cl
- Book at
- pullmanbus.cl
- Salón Cama
- $14–35
- [email protected]
- Website
- Expreso Santa Cruz
Bus from Terminal Sur de Santiago to Terminal de Buses Santa Cruz
- Ave. Duration
- 3h
- Frequency
- Every 30 minutes
- Estimated price
- $7
- Schedules at
- Expreso Santa Cruz
- Phone
- +56 22 683 8528
- [email protected]
- Website
- Andimar
Bus from Terminal Sur de Santiago to Terminal de Buses Santa Cruz
- Ave. Duration
- 2h 50m
- Frequency
- Hourly
- Estimated price
- $4–11
- Schedules at
- Andimar
- Semi Cama
- $4–9
- Cama
- $5–11
Bus from Terminal Sur de Santiago to Terminal de Buses Santa Cruz
- Ave. Duration
- 3h 20m
- Frequency
- Every 30 minutes
- Estimated price
- $4–11
- Schedules at
- TranSantin
- Road
- $4–11
- Phone
- +56 2 2666 5505
- [email protected]
- Website
- Buses Jetsur
Bus from Terminal Sur de Santiago to Terminal de Buses Santa Cruz
- Ave. Duration
- 3h 13m
- Frequency
- 4 times a day
- Estimated price
- $10–13
- Website
- Buses Jetsur
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