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How to get fromMemphis to Florenceby plane, bus (Greyhound), car, bus, or train

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There are 5 ways to get from Memphis to Florence by plane, bus (Greyhound), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Regional Airport

    best
    1. Fly from Memphis (MEM) to Florence Regional Airport (FLO)plane plane MEM - FLO
    5h 20m
    $91–484

  2. Bus (Greyhound)

    1. Take the bus from Memphis Bus Station to Atlanta Bus Stationbus bus Greyhound US0610
    2. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus Greyhound US0641S / ...
    16h 41m
    $116–181

  3. Drive  667.2 mi

    1. Drive from Memphis to Florencecar car 667.2 mi
    11h 7m
    $122–176

  4. Fly to Myrtle Beach, bus

    1. Fly from Memphis (MEM) to Myrtle Beach (MYR)plane plane MEM - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    7h 39m
    $99–473

  5. Fly to Fayetteville Municipal Airport, train

    1. Fly from Memphis (MEM) to Fayetteville Municipal Airport (FAY)plane plane MEM - FAY
    2. Take the train from Fayetteville Amtrak Station to Florence Stationtrain train
    8h 8m
    $147–570

Memphis to Florence by bus (Greyhound)

Calendar14Weekly Buses
Duration16h 41mAverage Duration
Ticket$116Cheapest Price
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Comparing Your Travel Options

Map of how to get from Memphis to Florence.ExpandLaunch map view
  • Distance: 600.3 mi
  • Duration: 5h 20m

What companies run services between Memphis, TN, USA and Florence, SC, USA?

American Airlines flies from Memphis (MEM) to Florence Regional Airport (FLO) 6 times a week. Alternatively, you can take a bus from 2ND STREET at ADAMS AVENUE to Florence Bus Station via Memphis Bus Station and Atlanta Bus Station in around 16h 41m.

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