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How to get fromMemphis to Mayo Clinicby plane, bus, train, car, bus (Greyhound, Flixbus), or bus (Flixbus)

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There are 7 ways to get from Memphis to Mayo Clinic by plane, bus, train, car, bus (Greyhound, Flixbus), or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Memphis (MEM) to Rochester (RST)plane plane MEM - RST
    6h 54m
    $115–572

  2. Bus

    1. Take the bus from Tornado Bus Co - West Memphis to Water & Chicago - Circle Kbus bus Milwaukee
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson 966 / ...
    18h 32m
    $191–355

  3. Bus, train

    1. Take the bus from Tornado Bus Co - West Memphis to Anna - Shellbus bus
    2. Take the train from Carbondale to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochester, MNbus bus
    21h 12m
    $379–760

  4. Drive 716.3 mi

    1. Drive from Memphis to Mayo Cliniccar car 716.3 mi
    12h 27m
    $131–189

  5. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Memphis (MEM) to Minneapolis–Saint Paul International Airport (MSP)plane plane MEM - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 37m
    $173–703

  6. Bus via Chicago

    1. Take the bus from Memphis Bus Station to Chicago Bus Stationbus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    21h 5m
    $161–301

  7. Bus via Springfield

    1. Take the bus from Memphis Bus Station to Springfield SMTD Transfer Centerbus bus
    2. Take the bus from Springfield SMTD Transfer Center to Chicago Bus Stationbus bus
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    23h 35m
    $201–321

Memphis (MEM) to Rochester (RST) flights

Calendar42Weekly Planes
Duration6h 13mAverage Duration
Ticket$105Cheapest Price
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Questions & Answers

Map of how to get from Memphis to Mayo Clinic.ExpandLaunch map view
  • Distance: 648.6 mi
  • Duration: 6h 54m

What companies run services between Memphis, TN, USA and Mayo Clinic, MN, USA?

Delta, American Airlines, and United Airlines fly from Memphis (MEM) to Rochester (RST) every 4 hours. Alternatively, you can take a vehicle from Memphis to Mayo Clinic via Tornado Bus Co - West Memphis, Water & Chicago - Circle K, Milwaukee, and Rochester in around 18h 32m.

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