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How to get fromMequon to Louisvilleby train, bus, bus (Greyhound, Flixbus, Amtrak), car, plane, bus (Amtrak), or subway

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There are 8 ways to get from Mequon to Louisville by train, bus, bus (Greyhound, Flixbus, Amtrak), car, plane, bus (Amtrak), or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus (Amtrak)

    best
    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    10h 48m
    $209–340

  2. Drive  397.5 mi

    cheapest
    1. Drive from Mequon to Louisvillecar car 397.5 mi
    7h 10m
    $73–105

  3. Bus

    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus Greyhound US0150
    2. Take the bus from Chicago Union Station to Louisville, KYbus bus Chicago
    11h 22m
    $82–107

  4. Fly General Mitchell International Airport to Louisville International Airport

    1. Fly from General Mitchell International Airport (MKE) to Louisville International Airport (SDF)plane plane MKE - SDF
    6h 37m
    $147–833

  5. Bus via Chicago O'Hare Airport (ORD)

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus Wisconsin Coach Lines
    2. Take the bus from Chicago Union Station to Louisville, KYbus bus Chicago
    12h 25m
    $111–133

  6. Bus to Chicago O'Hare International Airport, fly to Louisville International Airport

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane plane ORD - SDF
    7h 10m
    $127–548

  7. Bus to Chicago O'Hare International Airport, fly to Blue Grass Airport, drive

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    7h 11m
    $109–354

  8. Line 12 bus, train, subway to Chicago Midway International Airport, fly to Louisville International Airport

    1. Take the bus from Service Road & Schroeder to N5 & Clybournbus bus
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    3. Take the subway from LaSalle/Van Buren to Midwaysubway subway
    4. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    7h 49m
    $166–856

General Mitchell International Airport (MKE) to Louisville International Airport (SDF) flights

Calendar99Weekly Planes
Duration4h 23mAverage Duration
Ticket$126Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mequon to Louisville.ExpandLaunch map view
  • Distance: 411.3 mi
  • Duration: 10h 48m

What companies run services between Mequon, WI, USA and Louisville, KY, USA?

You can take a vehicle from Mequon to Louisville, KY via Service Road & Schroeder, N5 & Clybourn, Milwaukee Intermodal Station, Chicago Bus Station, and Chicago Union Station in around 11h 22m. Alternatively, Southwest Airlines, American Airlines, and two other airlines fly from General Mitchell International Airport (MKE) to Louisville International Airport (SDF) hourly.

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Train operators
Bus operators

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