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How to get fromMequon to Louisvilleby bus (Greyhound, Flixbus), train, bus, car, plane, shuttle, or subway

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There are 8 ways to get from Mequon to Louisville by bus (Greyhound, Flixbus), train, bus, car, plane, shuttle, or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus Greyhound US0150
    2. Take the bus from Chicago Bus Station to Louisville Bus Stationbus bus Greyhound US0100
    10h 33m
    $70–127

  2. Train, bus

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    10h 43m
    $136–265

  3. Drive  397.5 mi

    1. Drive from Mequon to Louisvillecar car 397.5 mi
    7h 10m
    $73–105

  4. Fly General Mitchell International Airport to Louisville International Airport

    1. Fly from General Mitchell International Airport (MKE) to Louisville International Airport (SDF)plane plane MKE - SDF
    6h 27m
    $137–733

  5. Bus, shuttle

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Take a shuttle bus from O'Hare International Terminal 2 to West Lafayette, INshuttle bus
    3. Take the bus from Lafayette Amtrak Station to Louisville, KYbus bus
    14h 4m
    $117–176

  6. Bus to Chicago O'Hare International Airport, fly to Louisville International Airport

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane plane ORD - SDF
    7h 8m
    $122–508

  7. Bus to Chicago O'Hare International Airport, fly to Blue Grass Airport, drive

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    7h 18m
    $109–374

  8. Line 12 bus, train, subway to Chicago Midway International Airport, fly to Louisville International Airport

    1. Take the bus from Service Road & Schroeder to N5 & Clybournbus bus
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    3. Take the subway from Adams/Wabash to Midwaysubway subway
    4. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    7h 36m
    $131–684

General Mitchell International Airport (MKE) to Louisville International Airport (SDF) flights

Calendar111Weekly Planes
Duration4h 20mAverage Duration
Ticket$111Cheapest Price
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Questions & Answers

Map of how to get from Mequon to Louisville.ExpandLaunch map view
  • Distance: 404.6 mi
  • Duration: 10h 33m

What companies run services between Mequon, WI, USA and Louisville, KY, USA?

You can take a vehicle from Mequon to Louisville Bus Station via Service Road & Schroeder, N5 & Clybourn, Milwaukee Intermodal Station, and Chicago Bus Station in around 10h 33m. Alternatively, Southwest Airlines, Delta, and two other airlines fly from General Mitchell International Airport (MKE) to Louisville International Airport (SDF) hourly.

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