There are 6 ways to get from Mesa to Buffalo by plane, bus, train, bus (Greyhound, Flixbus), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Buffalo Niagara International Airport
best- Fly from Phoenix (PHX) to Buffalo Niagara International Airport (BUF)plane PHX - BUF
7h 3m$177–780Bus, train
- Take the bus from Phoenix Sky Harbor Airport/44th Street Sky Train Station to Flagstaff Train Stationbus
- Take the train from Flagstaff to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Buffalo Depew Stationtrain
2d 2h$566–1,487Bus
- Take the bus from Love's Chandler to 285 S East End Ave - Pomonabus
- Take the bus from Montclair Transcenter to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Columbusbus
- Take the bus from Columbus to Buffalobus
2d 20h$519–808Drive 2,174.6 mi
- Drive from Mesa to Buffalocar 2,174.6 mi
35h 39m$397–574Fly to Rochester, bus
- Fly from Phoenix (PHX) to Rochester (ROC)plane PHX - ROC
- Take the bus from Rochester Bus Stop to Buffalobus
10h 17m$261–1,043Fly to Toronto Pearson International Airport, bus
- Fly from Phoenix (PHX) to Toronto Pearson International Airport (YYZ)plane PHX - YYZ
- Take the bus from Toronto Pearson Airport to Buffalobus
11h 7m$246–724
Mesa to Buffalo by tram, bus, and train
Comparing Your Travel Options
The cheapest way to get from Mesa to Buffalo is to fly and bus which costs $240 - $750 and takes 11h 7m.
The fastest way to get from Mesa to Buffalo is to fly which takes 7h 3m and costs $170 - $800.
No, there is no direct bus from Mesa to Buffalo. However, there are services departing from Love's Chandler and arriving at Buffalo via East End Ave and Mission Blvd E, Montclair Transcenter, St Louis Bus Station, S Grant Ave & E Mound St and Columbus. The journey, including transfers, takes approximately 2 days 20h.
The distance between Mesa and Buffalo is 1940 miles. The road distance is 2187.3 miles.
The best way to get from Mesa to Buffalo without a car is to bus and train which takes 2 days 2h and costs $550 - $1,500.
It takes approximately 7h 3m to get from Mesa to Buffalo, including transfers.
Mesa to Buffalo bus services, operated by Tufesa, depart from Love's Chandler station.
The best way to get from Mesa to Buffalo is to fly which takes 7h 3m and costs $170 - $800. Alternatively, you can bus, which costs $500 - $850 and takes 2 days 20h.
Mesa to Buffalo bus services, operated by Tufesa, arrive at 285 S East End Ave - Pomona station.
Buffalo is 3h ahead of Mesa. It is currently 5:44 AM in Mesa and 8:44 AM in Buffalo.
What companies run services between Mesa, AZ, USA and Buffalo, NY, USA?
Southwest Airlines, Delta, and two other airlines fly from Phoenix (PHX) to Buffalo Niagara International Airport (BUF) every 4 hours. Alternatively, you can take a vehicle from Mesa to Buffalo via Love's Chandler, 285 S East End Ave - Pomona, East End Ave and Mission Blvd E, Montclair Transit Center, Montclair Transcenter, St Louis Bus Station, Columbus, S Grant Ave & E Mound St, S High St & E Rich St, and Columbus in around 2d 20h.
- Website
- southwest.com
Flights from Phoenix to Buffalo Niagara International Airport
- Ave. Duration
- 4h 3m
- When
- Every day
- Estimated price
- $170–750
Flights from Phoenix to Buffalo Niagara International Airport via Chicago Midway
- Ave. Duration
- 5h 45m
- When
- Sunday, Tuesday, and Wednesday
- Estimated price
- $170–750
Flights from Phoenix to Buffalo Niagara International Airport via Denver
- Ave. Duration
- 5h 55m
- When
- Sunday
- Estimated price
- $170–750
Flights from Phoenix to Buffalo Niagara International Airport via Baltimore
- Ave. Duration
- 6h 25m
- When
- Friday, Monday, and Thursday
- Estimated price
- $190–850
Flights from Phoenix to Rochester via Chicago Midway
- Ave. Duration
- 6h 15m
- When
- Every day
- Estimated price
- $230–1,000
Flights from Phoenix to Rochester via Baltimore
- Ave. Duration
- 8h 25m
- When
- Saturday, Tuesday, Wednesday, and Friday
- Estimated price
- $260–1,100
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Flagstaff to Chicago Union Station
- Ave. Duration
- 32h 43m
- Frequency
- Once daily
- Estimated price
- $410–1,000
- Website
- Amtrak
Train from Chicago Union Station to Buffalo Depew Station
- Ave. Duration
- 10h 23m
- Frequency
- Twice daily
- Estimated price
- $130–310
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Phoenix Sky Harbor Airport/44th Street Sky Train Station to Flagstaff Train Station
- Ave. Duration
- 2h 25m
- Frequency
- Once daily
- Estimated price
- $22–35
- Schedules at
- Flixbus USA
Bus from Columbus to Buffalo
- Ave. Duration
- 6h 25m
- Frequency
- 6 times a week
- Estimated price
- $45–75
- Schedules at
- Flixbus USA
Bus from Rochester Bus Stop to Buffalo
- Ave. Duration
- 1h 30m
- Frequency
- Every 4 hours
- Estimated price
- $11–17
- Schedules at
- Flixbus USA
Bus from Toronto Pearson Airport to Buffalo
- Ave. Duration
- 3h 10m
- Frequency
- 5 times a week
- Estimated price
- $14–22
- Schedules at
- Flixbus USA
Want to know more about travelling around United States
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Booking & Getting There
Yes, the driving distance between Mesa to Buffalo is 2187 miles. It takes approximately 35h 39m to drive from Mesa to Buffalo.
There are 257+ hotels available in Buffalo.







