There are 6 ways to get from Mesa to Des Moines by plane, bus, train, car, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Phoenix
best- Fly from Phoenix (PHX) to Des Moines (DSM)plane PHX - DSM
4h 45m$100–425Bus via Ciudad Juárez
- Take the bus from Phoenix to El Pasobus La
- Take the bus from El Paso to 2745 Southwest Blvd - Kansas Citybus
- Take the bus from Kansas City to Des Moinesbus
32h 56m$252–362Bus, train
- Take the bus from Phoenix Sky Harbor Airport/44th Street Sky Train Station to Flagstaff Train Stationbus
- Take the train from Flagstaff to Kansas Citytrain
- Take the bus from Kansas City Bus Station to Des Moinesbus
34h 30m$354–837Drive 1,376.6 mi
- Drive from Mesa to Des Moinescar 1,376.6 mi
24h 12m$252–363Fly from Phoenix-Mesa Gateway Airport
- Fly from Phoenix-Mesa Gateway Airport (AZA) to Des Moines (DSM)plane AZA - DSM
5h 5m$122–517Bus
- Take the bus from Phoenix Bus Station to Tulsa Bus Stationbus Greyhound US1210
- Take the bus from Tulsa to Des Moinesbus Jefferson Lines 802
34h 43m$272–432
Mesa to Des Moines by tram, bus, and foot
Comparing Your Travel Options
The cheapest way to get from Mesa to Des Moines is to fly which costs $100 - $430 and takes 4h 45m.
The fastest way to get from Mesa to Des Moines is to fly which takes 4h 45m and costs $100 - $430.
No, there is no direct bus from Mesa to Des Moines. However, there are services departing from Phoenix and arriving at Des Moines via El Paso, On Sw Blvd At 27Th Northbound Nearside and Kansas City. The journey, including transfers, takes approximately 32h 56m.
The distance between Mesa and Des Moines is 1173 miles. The road distance is 1384.7 miles.
The best way to get from Mesa to Des Moines without a car is to bus via Ciudad Juárez which takes 32h 56m and costs $250 - $370.
It takes approximately 4h 45m to get from Mesa to Des Moines, including transfers.
Mesa to Des Moines bus services, operated by Limousine Express, depart from Phoenix station.
The best way to get from Mesa to Des Moines is to fly which takes 4h 45m and costs $100 - $430. Alternatively, you can bus via Ciudad Juárez, which costs $250 - $370 and takes 32h 56m.
Mesa to Des Moines bus services, operated by Limousine Express, arrive at El Paso station.
Des Moines is 2h ahead of Mesa. It is currently 6:01 AM in Mesa and 8:01 AM in Des Moines.
What companies run services between Mesa, AZ, USA and Des Moines, IA, USA?
American Airlines, Southwest Airlines, and two other airlines fly from Phoenix (PHX) to Des Moines (DSM) every 3 hours. Alternatively, you can take a vehicle from Mesa Dr/Main St to Des Moines via 24th St/Washington, Phoenix, El Paso, El Paso, 2745 Southwest Blvd - Kansas City, On Sw Blvd At 27Th Northbound Nearside, On 12Th At Troost Eastbound, and Kansas City in around 32h 56m.
- Website
- southwest.com
Flights from Phoenix to Des Moines
- Ave. Duration
- 2h 45m
- When
- Sunday
- Estimated price
- $80–400
Flights from Phoenix to Des Moines via Denver
- Ave. Duration
- 4h 33m
- When
- Saturday, Sunday, Monday, Thursday, and Friday
- Estimated price
- $80–410
Flights from Phoenix to Des Moines via Las Vegas
- Ave. Duration
- 5h 25m
- When
- Monday, Thursday, and Friday
- Estimated price
- $95–450
Flights from Phoenix to Des Moines via Chicago Midway
- Ave. Duration
- 5h 35m
- When
- Saturday, Tuesday, and Wednesday
- Estimated price
- $110–500
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Flagstaff to Kansas City
- Ave. Duration
- 24h 27m
- Frequency
- Once daily
- Estimated price
- $300–750
- Website
- Amtrak
- Phone
- +1 866 691 9732
- [email protected]
- Website
- Limousine Express
Bus from Phoenix to El Paso
- Ave. Duration
- 6h 45m
- Frequency
- 5 times a day
- Estimated price
- $60–90
- Website
- Limousine Express
- One Way
- $60–90
Want to know more about travelling around United States
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Booking & Getting There
Yes, the driving distance between Mesa to Des Moines is 1385 miles. It takes approximately 24h 12m to drive from Mesa to Des Moines.
Book your Mesa to Des Moines bus tickets online with Omio.
There are 248+ hotels available in Des Moines.










