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How to get fromMesa to Des Moinesby plane, bus, train, bus (Greyhound), or car

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There are 4 ways to get from Mesa to Des Moines by plane, bus, train, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Phoenix (PHX) to Des Moines (DSM)plane plane PHX - DSM
    4h 45m
    $219–723

  2. Bus, train

    1. Take the bus from Tempe to Flagstaff Train Stationbus bus
    2. Take the train from Flagstaff to Kansas Citytrain train
    3. Take the bus from Kansas City to Des Moinesbus bus
    34h 25m
    $476–967

  3. Bus

    1. Take the bus from Phoenix Sky Harbor Airport/44th Street Sky Train Station to El Paso Bus Stationbus bus
    2. Take the bus from El Paso Bus Station to Denverbus bus
    3. Take the bus from Denver Union Station to Des Moinesbus bus
    36h 25m
    $281–477

  4. Drive 1,376.6 mi

    1. Drive from Mesa to Des Moinescar car 1,376.6 mi
    24h 12m
    $252–363

Mesa to Des Moines by bus and foot

Calendar7Weekly Services
Duration36h 25mAverage Duration
Ticket$281Cheapest Price
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Questions & Answers

Map of how to get from Mesa to Des Moines.ExpandLaunch map view
  • Distance: 1,166.5 mi
  • Duration: 4h 45m

What companies run services between Mesa, AZ, USA and Des Moines, IA, USA?

American Airlines, Southwest Airlines, and three other airlines fly from Phoenix (PHX) to Des Moines (DSM) every 3 hours. Alternatively, you can take a bus from University Dr & Mesa Dr to Des Moines via University Dr & Rural Rd, Tempe, Phoenix Sky Harbor Airport/44th Street Sky Train Station, El Paso Bus Station, Denver, 18th St & California St, Union Station Gate B2, and Denver Union Station in around 36h 25m.

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