There are 6 ways to get from Mesa to Louisville by plane, bus (Greyhound), bus, train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Louisville International Airport
best- Fly from Phoenix (PHX) to Louisville International Airport (SDF)plane PHX - SDF
6h 20m$183–855Fly to Blue Grass Airport, drive
cheapest- Fly from Phoenix (PHX) to Blue Grass Airport (LEX)plane PHX - LEX
- Drive from Lexington-Airport-LEX to Louisvillecar
8h 52m$114–491Bus
- Take the bus from Phoenix Bus Station to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Evansville Bus Stationbus
- Take the bus from Evansville, IN to Louisville, KYbus
40h 15m$360–618Bus, train via Chicago
- Take the bus from Phoenix Sky Harbor Airport/44th Street Sky Train Station to Flagstaff Train Stationbus
- Take the train from Flagstaff to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Indianapolistrain
- Take the bus from Indianapolis Union Station to Louisville, KYbus
46h 38m$1,047–1,752Drive 1,697.3 mi
- Drive from Mesa to Louisvillecar 1,697.3 mi
27h 18m$300–434Bus, train
- Take the bus from Tempe to Tucson Downtownbus
- Take the train from Tucson Amtrak Station to St. Louistrain
- Take the bus from St Louis Bus Station to Evansville Bus Stationbus
- Take the bus from Evansville, IN to Louisville, KYbus
2d 9h$1,084–1,908
Mesa to Louisville by bus and taxi
Comparing Your Travel Options
The cheapest way to get from Mesa to Louisville is to fly and drive which costs $110 - $500 and takes 8h 52m.
The fastest way to get from Mesa to Louisville is to fly which takes 6h 20m and costs $180 - $900.
No, there is no direct bus from Mesa to Louisville. However, there are services departing from University Dr & Mesa Dr and arriving at Louisville, KY via Phoenix Bus Station, St Louis Bus Station and Evansville, IN. The journey, including transfers, takes approximately 40h 15m.
The distance between Mesa and Louisville is 1529 miles. The road distance is 1707.2 miles.
The best way to get from Mesa to Louisville without a car is to bus which takes 40h 15m and costs $360 - $650.
It takes approximately 6h 20m to get from Mesa to Louisville, including transfers.
Mesa to Louisville bus services, operated by Greyhound USA, depart from Phoenix Bus Station.
The best way to get from Mesa to Louisville is to fly which takes 6h 20m and costs $180 - $900. Alternatively, you can bus, which costs $360 - $650 and takes 40h 15m.
Mesa to Louisville bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Louisville is 2h ahead of Mesa. It is currently 9:10 PM in Mesa and 11:10 PM in Louisville.
What companies run services between Mesa, AZ, USA and Louisville, KY, USA?
Southwest Airlines, United Airlines, and American Airlines fly from Phoenix (PHX) to Louisville International Airport (SDF) every 4 hours. Alternatively, you can take a bus from University Dr & Mesa Dr to Louisville, KY via 24th St/Baseline PNR, Phoenix Bus Station, St Louis Bus Station, and Evansville, IN in around 40h 15m.
- Website
- aa.com
Flights from Phoenix to Louisville International Airport via Dallas/Ft.Worth
- Ave. Duration
- 5h 45m
- When
- Every day
- Estimated price
- $190–900
Flights from Phoenix to Blue Grass Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h 13m
- When
- Every day
- Estimated price
- $100–470
Flights from Phoenix to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 7h 51m
- When
- Every day
- Estimated price
- $110–480
Flights from Phoenix to Blue Grass Airport via Charlotte
- Ave. Duration
- 7h 45m
- When
- Every day
- Estimated price
- $120–550
- Website
- southwest.com
Flights from Phoenix to Louisville International Airport
- Ave. Duration
- 3h 20m
- When
- Every day
- Estimated price
- $180–850
Flights from Phoenix to Louisville International Airport via Nashville
- Ave. Duration
- 5h 5m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $190–900
Flights from Phoenix to Louisville International Airport via Chicago Midway
- Ave. Duration
- 5h 27m
- When
- Saturday, Tuesday, and Wednesday
- Estimated price
- $200–900
Flights from Phoenix to Louisville International Airport via Denver
- Ave. Duration
- 5h 32m
- When
- Tuesday, Wednesday, Monday, Thursday, Friday, and Sunday
- Estimated price
- $200–900
Flights from Phoenix to Louisville International Airport via Dallas
- Ave. Duration
- 5h 45m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $190–900
- Website
- delta.com
Flights from Phoenix to Blue Grass Airport via Atlanta
- Ave. Duration
- 6h 54m
- When
- Every day
- Estimated price
- $110–500
Flights from Phoenix to Blue Grass Airport via Detroit
- Ave. Duration
- 7h 40m
- When
- Every day
- Estimated price
- $120–550
- Website
- united.com
Flights from Phoenix to Louisville International Airport via Denver
- Ave. Duration
- 5h 48m
- When
- Every day
- Estimated price
- $200–900
Flights from Phoenix to Blue Grass Airport via Denver
- Ave. Duration
- 5h 46m
- When
- Every day
- Estimated price
- $100–470
Flights from Phoenix to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 6h 51m
- When
- Every day
- Estimated price
- $110–480
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Flagstaff to Chicago Union Station
- Ave. Duration
- 32h 43m
- Frequency
- Once daily
- Estimated price
- $900–1,500
- Website
- Amtrak
Train from Chicago Union Station to Indianapolis
- Ave. Duration
- 4h 54m
- Frequency
- 3 times a week
- Estimated price
- $100–170
- Website
- Amtrak
Train from Tucson Amtrak Station to St. Louis
- Ave. Duration
- 45h 37m
- Frequency
- 3 times a week
- Estimated price
- $1,000–1,700
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Phoenix Bus Station to St Louis Bus Station
- Ave. Duration
- 30h 25m
- Frequency
- Twice daily
- Estimated price
- $280–420
- Website
- Greyhound
Bus from St Louis Bus Station to Evansville Bus Station
- Ave. Duration
- 3h 25m
- Frequency
- Twice daily
- Estimated price
- $30–50
- Website
- Greyhound
Bus from St Louis Bus Station to Evansville Bus Station
- Ave. Duration
- 3h 25m
- Frequency
- Twice daily
- Estimated price
- $30–50
- Website
- Greyhound
- Phone
- +1 502-368-5644 x 135
- Website
- Miller Transportation
Bus from Evansville, IN to Louisville, KY
- Ave. Duration
- 2h 15m
- Frequency
- Once daily
- Estimated price
- $35–130
- Website
- Miller Transportation
Bus from Evansville, IN to Louisville, KY
- Ave. Duration
- 2h 15m
- Frequency
- Once daily
- Estimated price
- $35–130
- Website
- Miller Transportation
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Phoenix Sky Harbor Airport/44th Street Sky Train Station to Flagstaff Train Station
- Ave. Duration
- 2h 25m
- Frequency
- Once daily
- Estimated price
- $23–35
- Schedules at
- Flixbus USA
Bus from Tempe to Tucson Downtown
- Ave. Duration
- 1h 45m
- Frequency
- 4 times a day
- Estimated price
- $17–26
- Schedules at
- Flixbus USA
Rome2Rio's guide to Amtrak Thruway
Contact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Indianapolis Union Station to Louisville, KY
- Ave. Duration
- 1h 55m
- Frequency
- Twice daily
- Estimated price
- $22–45
- Website
- Amtrak
- Adult
- $22–45
Want to know more about travelling around United States
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Booking & Getting There
Yes, the driving distance between Mesa to Louisville is 1707 miles. It takes approximately 27h 18m to drive from Mesa to Louisville.
Book your Mesa to Louisville bus tickets online with Omio.
There are 29+ hotels available in Louisville.













