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How to get fromMesa to San Luis Obispoby tram, plane, bus (Greyhound, Flixbus), taxi, train, car, or bus

Find Transport to San Luis Obispo

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There are 8 ways to get from Mesa to San Luis Obispo by tram, plane, bus (Greyhound, Flixbus), taxi, train, car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Tram, fly to San Luis Obispo County Regional Airport

    best
    1. Take the tram from Center/Main St to 44th St/Washingtontram tram
    2. Fly from Phoenix (PHX) to San Luis Obispo County Regional Airport (SBP)plane plane PHX - SBP
    4h 33m
    $183–254

  2. Bus

    cheapest
    1. Take the bus from Phoenix Bus Station to Los Angeles Union Stationbus bus Greyhound US1000 / ...
    2. Take the bus from Los Angeles Union Station to San Luis Obispo Railroad Museumbus bus FlixBus 2005
    14h 43m
    $87–162

  3. Taxi, train

    1. Take the taxi from Mesa to Maricopa Amtraktaxi taxi
    2. Take the train from Maricopa Amtrak to Los Angelestrain train
    3. Take the train from Los Angeles to San Luis Obispotrain train
    15h 18m
    $288–533

  4. Drive 571.6 mi

    1. Drive from Mesa to San Luis Obispocar car 571.6 mi
    9h 42m
    $105–151

  5. Fly to Santa Barbara Municipal Airport, bus

    1. Fly from Phoenix (PHX) to Santa Barbara Municipal Airport (SBA)plane plane PHX - SBA
    2. Take the bus from Uc Santa Barbara Amtrak Bus Stop to San Luis Obispobus bus
    7h 1m
    $193–424

  6. Bus, train

    1. Take the bus from Phoenix Bus Station to Los Angeles Union Stationbus bus Greyhound US1000 / ...
    2. Take the train from Los Angeles to San Luis Obispotrain train Coast Starlight / ...
    15h 13m
    $127–262

  7. Bus, train via San Bernardino

    1. Take the bus from Phoenix to San Bernardino, CAbus bus
    2. Take the train from San Bernardino - Downtown to L.A. Union Stationtrain train
    3. Take the train from Los Angeles to San Luis Obispotrain train
    16h 51m
    $133–243

  8. Bus, train via Van Nuys

    1. Take the bus from Phoenix to Los Angeles - Pacoimabus bus Nogales
    2. Take the train from Van Nuys to San Luis Obispotrain train Coast Starlight / ...
    17h 43m
    $117–223

Mesa to San Luis Obispo by bus

Calendar8Weekly Buses
Duration14h 43mAverage Duration
Ticket$87Cheapest Price
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Questions & Answers

Map of how to get from Mesa to San Luis Obispo.ExpandLaunch map view
  • Distance: 524.5 mi
  • Duration: 4h 33m

What companies run services between Mesa, AZ, USA and San Luis Obispo, CA, USA?

You can take a bus from University Dr & Mesa Dr to San Luis Obispo Railroad Museum via 24th St/Baseline PNR, 24th St & Buckeye Rd, Phoenix Bus Station, and Los Angeles Union Station in around 14h 43m.

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